Synthesis and antiinflammatory activity of some new indolyl substituted quinazolin-4-(3H)-ones

被引：0

作者：

Kumar, Pankaj ^{[1
]}

Rajput, Chatrasal Singh ^{[1
]}

Bhati, Sudhir Kumar ^{[1
]}

Rani, Parul ^{[1
]}

Singh, Jai ^{[1
]}

Yeshowardhan ^{[1
]}

Kumar, Ashok ^{[1
]}

机构：

[1] Devanagri Postgrad Coll, Dept Chem, Meerut 250002, Uttar Pradesh, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 03期

关键词：

synthesis; substituted quinazolin-4-(3H)-ones; antiinflammatory activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 2-methyl-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (1-2), 2-chloroacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (3-4), 2-hydrazinoacetylmethylene-3-(2 '-substituted-indol-3 '-yl)-substituted quinazolin-4(3H)-ones (5-6). 2-(substituted phenylmethyleneimino)aminoacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (7-14) and 2-(substituted phenylaminomethyleneacetyl-4 '-oxo-3 '-thiazatidinyl)-3-(2 ''-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (15-22) have been synthesized. The compounds were screened for their antiinflammatory activity and were compared with the standard drug phenylbutazone. Out of these compounds the most active was 2-(p-chlorophenyl aminomethylacetyl-4 '-oxo-1 '-thiazolidinyl)-3-(indol-3 '-yl)-6,8-dibromo quinazokin-4(3H)-one (19). The structures of these compounds have been confirmed by elemental and spectral analysis.

引用

页码：1827 / 1832

页数：6

共 50 条

[41] Synthesis and antimicrobial activity of some novel 2,3-disubstituted quinazolin-4(3H)ones
Abbas, Safinaz E. S.
Saafan, Amal E. M.
BULLETIN OF PHARMACEUTICAL SCIENCES, 2007, 30 : 51 - 62
[42] Synthesis of some new quinazolin-4(3H)-one derivatives and evaluation of their anticonvulsant activity
Boshta, Nader M.
El-Essawy, Farag A.
Ammar, Ramy M.
Ismail, Abd El-Hamid
Wahba, Nancy E.
MONATSHEFTE FUR CHEMIE, 2016, 147 (11): : 2031 - 2042
[43] Synthesis and pharmacological investigation of some novel 2,3-disubstituted quinazolin-4(3H)-ones as analgesic and antiinflammatory agents
Alagarsamy, V
Meena, S
Vijayakumar, S
Ramseshu, KV
Revathi, R
PHARMAZIE, 2003, 58 (04): : 233 - 236
[44] Synthesis of some new quinazolin-4(3H)-one derivatives and evaluation of their anticonvulsant activity
Nader M. Boshta
Farag A. El-Essawy
Ramy M. Ammar
Abd El-Hamid Ismail
Nancy E. Wahba
Monatshefte für Chemie - Chemical Monthly, 2016, 147 : 2031 - 2042
[45] Design and synthesis of novel 2-(3-substituted propyl)-3-(2-methyl phenyl) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents
Alagarsamy, V.
Parthiban, P.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 28 (01) : 65 - 71
[46] Synthesis of 6-Substituted 3(H)-Quinazolin-4-Ones and Their Antimicrobial Activity
Ziyadullaev, Mirjalol
Karimov, Rikhsiboy
Abdurazakhov, Asqar
Parmanov, Asqar
Sasmakov, Sobirdjan
Abdurakhmanov, Jaloliddin
Eshboev, Farkhod
Azimova, Shakhnoz
PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 57 (03) : 373 - 377
[47] Synthesis of 6-Substituted 3(H)-Quinazolin-4-Ones and Their Antimicrobial Activity
Mirjalol Ziyadullaev
Rikhsiboy Karimov
Asqar Abdurazakhov
Asqar Parmanov
Sobirdjan Sasmakov
Jaloliddin Abdurakhmanov
Farkhod Eshboev
Shakhnoz Azimova
Pharmaceutical Chemistry Journal, 2023, 57 : 373 - 377
[48] Synthesis and anti-inflammatory activity of some new 2,3-disubstituted-6-monosubstituted-quinazolin-4(3H)-ones
Rani, P
Archana
Srivastava, VK
Kumar, A
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2002, 41 (12): : 2642 - 2646
[49] 2-Substituted-mercapto-quinazolin-4(3H)-ones as DHFR Inhibitors
El-Subbagh, Hussein I.
Sabry, Mohamed A.
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021, 21 (16) : 2249 - 2260
[50] Synthesis, characterization and anti-bacterial activity of some new 2, 3, 6-trisubstituted quinazolin-4(3H)-ones
Patel, RD
Patel, MP
Patel, RG
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2005, 44 (09): : 1944 - 1946

← 1 2 3 4 5 →