Synthesis and antiinflammatory activity of some new indolyl substituted quinazolin-4-(3H)-ones

被引：0
|
作者：
Kumar, Pankaj [1 ]
Rajput, Chatrasal Singh [1 ]
Bhati, Sudhir Kumar [1 ]
Rani, Parul [1 ]
Singh, Jai [1 ]
Yeshowardhan [1 ]
Kumar, Ashok [1 ]
机构：
[1] Devanagri Postgrad Coll, Dept Chem, Meerut 250002, Uttar Pradesh, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 03期
关键词：
synthesis; substituted quinazolin-4-(3H)-ones; antiinflammatory activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2-methyl-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (1-2), 2-chloroacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (3-4), 2-hydrazinoacetylmethylene-3-(2 '-substituted-indol-3 '-yl)-substituted quinazolin-4(3H)-ones (5-6). 2-(substituted phenylmethyleneimino)aminoacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (7-14) and 2-(substituted phenylaminomethyleneacetyl-4 '-oxo-3 '-thiazatidinyl)-3-(2 ''-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (15-22) have been synthesized. The compounds were screened for their antiinflammatory activity and were compared with the standard drug phenylbutazone. Out of these compounds the most active was 2-(p-chlorophenyl aminomethylacetyl-4 '-oxo-1 '-thiazolidinyl)-3-(indol-3 '-yl)-6,8-dibromo quinazokin-4(3H)-one (19). The structures of these compounds have been confirmed by elemental and spectral analysis.
引用
收藏
页码：1827 / 1832
页数：6
相关论文
共 50 条
  • [31] Some new quinazolin-4(3H)-one derivatives, synthesis and antitumor activity
    Alafeefy, Ahmed Mahmoud
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2011, 15 (04) : 337 - 343
  • [32] Synthesis and Antibacterial Activity of Some New 4(3H)Quinazolin-4-one Derivatives
    Azab, M. E.
    Kassab, E. A.
    El-Hashash, M. A.
    Ali, R. S.
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2009, 184 (03) : 610 - 625
  • [33] Synthesis and Antimicrobial Activity of Some New Quinazolin-4(3H)-one Derivatives
    Alafeefy, Ahmed M.
    PHARMACEUTICAL BIOLOGY, 2008, 46 (10-11) : 751 - 756
  • [34] Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones
    Raghavendra, N. M.
    Thampi, P. P.
    Gurubasavarajaswamy, P. M.
    E-JOURNAL OF CHEMISTRY, 2008, 5 (01) : 23 - 33
  • [35] Design and Synthesis of Novel 3-(4-Chlorophenyl)-2-(3-Substituted Propyl Thio) Quinazolin-4-(3H)-ones as a New Class of H1-Antihistaminic Agents
    Alagarsamy, V.
    Parthiban, P.
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2012, 62 (09): : 433 - 438
  • [36] Convenient synthesis of 2,3-disubstituted quinazolin-4(3H)-ones and 2-styryl-3-substituted quinazolin-4(3H)-ones: applications towards the synthesis of drugs
    Kumar, Dinesh
    Jadhavar, Pradeep S.
    Nautiyal, Manesh
    Sharma, Himanshu
    Meena, Prahlad K.
    Adane, Legesse
    Pancholia, Sahaj
    Chakraborti, Asit K.
    RSC ADVANCES, 2015, 5 (39) : 30819 - 30825
  • [37] NMR studies of 3-substituted quinazolin-4(3H)-ones
    Georgescu, F
    Georgescu, EI
    Caproiu, MT
    Draghici, C
    REVUE ROUMAINE DE CHIMIE, 1999, 44 (04) : 341 - 350
  • [38] SYNTHESIS OF BENZOXAZOLYLTHIOMETHYL AND BENZTHIAZOLYLTHIOMETHYL QUINAZOLIN-4(3H)-ONES
    Rafeeq, Mohammad
    Reddy, Chittireddy Venkata Ramana
    Dubey, Pramod Kumar
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2015, 190 (11) : 1857 - 1864
  • [39] Synthesis of 2, 3-Disubstituted-Quinazolin-4-(3H)-ones
    Patil, D. A.
    Patil, P. O.
    Patil, G. B.
    Surana, S. J.
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2011, 11 (08) : 633 - 641
  • [40] Synthesis and Evaluation of Antioxidant Properties of 2-Substituted Quinazolin-4(3H)-ones
    Mravljak, Janez
    Slavec, Lara
    Hrast, Martina
    Sova, Matej
    MOLECULES, 2021, 26 (21):
12345