Synthesis and antiinflammatory activity of some new indolyl substituted quinazolin-4-(3H)-ones

被引：0
|
作者：
Kumar, Pankaj [1 ]
Rajput, Chatrasal Singh [1 ]
Bhati, Sudhir Kumar [1 ]
Rani, Parul [1 ]
Singh, Jai [1 ]
Yeshowardhan [1 ]
Kumar, Ashok [1 ]
机构：
[1] Devanagri Postgrad Coll, Dept Chem, Meerut 250002, Uttar Pradesh, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 03期
关键词：
synthesis; substituted quinazolin-4-(3H)-ones; antiinflammatory activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2-methyl-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (1-2), 2-chloroacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (3-4), 2-hydrazinoacetylmethylene-3-(2 '-substituted-indol-3 '-yl)-substituted quinazolin-4(3H)-ones (5-6). 2-(substituted phenylmethyleneimino)aminoacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (7-14) and 2-(substituted phenylaminomethyleneacetyl-4 '-oxo-3 '-thiazatidinyl)-3-(2 ''-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (15-22) have been synthesized. The compounds were screened for their antiinflammatory activity and were compared with the standard drug phenylbutazone. Out of these compounds the most active was 2-(p-chlorophenyl aminomethylacetyl-4 '-oxo-1 '-thiazolidinyl)-3-(indol-3 '-yl)-6,8-dibromo quinazokin-4(3H)-one (19). The structures of these compounds have been confirmed by elemental and spectral analysis.
引用
收藏
页码：1827 / 1832
页数：6
相关论文
共 50 条
  • [11] Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones
    Alagarsamy, V
    Murugananthan, G
    Venkateshperumal, R
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2003, 26 (12) : 1711 - 1714
  • [12] Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues
    Sathish, N. K.
    Shahensha, S.
    Ali, M. Irfan
    Chethan, I. A.
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2012, 46 (02) : 185 - 191
  • [13] Synthesis of New Quinazolin-4-(3H)-one Derivatives and Evaluation of Their Biological Activities
    Mostafavi, Hamid
    Islami, Mohammad Reza
    Khabazzadeh, Hojatollah
    Khaleghi, Moj
    CHEMISTRYSELECT, 2019, 4 (11): : 3169 - 3174
  • [14] A new approach to the facile synthesis of 2-substituted-quinazolin-4(3H)-ones
    Wang, Bin
    Li, Zeng
    Wang, Xiao Ning
    Tan, Jia Heng
    Gu, Lian Quan
    Huang, Zhi Shu
    CHINESE CHEMICAL LETTERS, 2011, 22 (08) : 951 - 953
  • [15] A new approach to the facile synthesis of 2-substituted-quinazolin-4(3H)-ones
    Bin Wang~(a
    ChineseChemicalLetters, 2011, 22 (08) : 951 - 953
  • [16] Green chemistry approach to the synthesis of 3-substituted-quinazolin-4(3H)-ones and 2-methyl-3-substituted-quinazolin-4(3H)-ones and biological evaluation
    Komar, Mario
    Molnar, Maja
    Jukic, Marijana
    Glavas-Obrovac, Ljubica
    Opacak-Bernardi, Teuta
    GREEN CHEMISTRY LETTERS AND REVIEWS, 2020, 13 (02) : 93 - 101
  • [17] Synthesis of some new quinazolin-4(3H)-ones as possible antimicrobial agents
    Mishra, P
    Jain, SK
    Jain, S
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1997, 74 (10) : 816 - 817
  • [18] A NOVEL SYNTHESIS OF 2-SUBSTITUTED QUINAZOLIN-4(3H)-ONES
    SVETLIK, J
    HETEROCYCLES, 1981, 16 (08) : 1281 - 1285
  • [19] Synthesis of quinazolin-4-(3H)-ones from o-amidobenzonitriles using urea hydrogen peroxide
    Bandgar, BP
    SYNTHETIC COMMUNICATIONS, 1997, 27 (12) : 2065 - 2068
  • [20] Synthesis and antimicrobial activity of 2-{1′[(4"-chlorophenyl)-2′-methylpropyl]-3N-(aryl) quinazolin-4-(3H) ones
    Radadia, VR
    Purohit, DM
    Patolia, VN
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2004, 14 (02) : 153 - 154
12345