Synthesis and antiinflammatory activity of some new indolyl substituted quinazolin-4-(3H)-ones

被引：0
|
作者：
Kumar, Pankaj [1 ]
Rajput, Chatrasal Singh [1 ]
Bhati, Sudhir Kumar [1 ]
Rani, Parul [1 ]
Singh, Jai [1 ]
Yeshowardhan [1 ]
Kumar, Ashok [1 ]
机构：
[1] Devanagri Postgrad Coll, Dept Chem, Meerut 250002, Uttar Pradesh, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 03期
关键词：
synthesis; substituted quinazolin-4-(3H)-ones; antiinflammatory activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2-methyl-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (1-2), 2-chloroacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (3-4), 2-hydrazinoacetylmethylene-3-(2 '-substituted-indol-3 '-yl)-substituted quinazolin-4(3H)-ones (5-6). 2-(substituted phenylmethyleneimino)aminoacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (7-14) and 2-(substituted phenylaminomethyleneacetyl-4 '-oxo-3 '-thiazatidinyl)-3-(2 ''-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (15-22) have been synthesized. The compounds were screened for their antiinflammatory activity and were compared with the standard drug phenylbutazone. Out of these compounds the most active was 2-(p-chlorophenyl aminomethylacetyl-4 '-oxo-1 '-thiazolidinyl)-3-(indol-3 '-yl)-6,8-dibromo quinazokin-4(3H)-one (19). The structures of these compounds have been confirmed by elemental and spectral analysis.
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页码：1827 / 1832
页数：6
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