Synthesis and antiinflammatory activity of some new indolyl substituted quinazolin-4-(3H)-ones

被引：0
|
作者：
Kumar, Pankaj [1 ]
Rajput, Chatrasal Singh [1 ]
Bhati, Sudhir Kumar [1 ]
Rani, Parul [1 ]
Singh, Jai [1 ]
Yeshowardhan [1 ]
Kumar, Ashok [1 ]
机构：
[1] Devanagri Postgrad Coll, Dept Chem, Meerut 250002, Uttar Pradesh, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 03期
关键词：
synthesis; substituted quinazolin-4-(3H)-ones; antiinflammatory activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2-methyl-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (1-2), 2-chloroacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (3-4), 2-hydrazinoacetylmethylene-3-(2 '-substituted-indol-3 '-yl)-substituted quinazolin-4(3H)-ones (5-6). 2-(substituted phenylmethyleneimino)aminoacetylmethylene-3-(2 '-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (7-14) and 2-(substituted phenylaminomethyleneacetyl-4 '-oxo-3 '-thiazatidinyl)-3-(2 ''-substituted indol-3 '-yl)-substituted quinazolin-4(3H)-ones (15-22) have been synthesized. The compounds were screened for their antiinflammatory activity and were compared with the standard drug phenylbutazone. Out of these compounds the most active was 2-(p-chlorophenyl aminomethylacetyl-4 '-oxo-1 '-thiazolidinyl)-3-(indol-3 '-yl)-6,8-dibromo quinazokin-4(3H)-one (19). The structures of these compounds have been confirmed by elemental and spectral analysis.
引用
收藏
页码：1827 / 1832
页数：6
相关论文
共 50 条
  • [1] Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents
    Mohd Amir
    Israr Ali
    Mohd Zaheen Hassan
    Archives of Pharmacal Research, 2013, 36 : 61 - 68
  • [2] Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents
    Amir, Mohd
    Ali, Israr
    Hassan, Mohd Zaheen
    ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (01) : 61 - 68
  • [3] Synthesis and Biological Activity of Some New Substituted Quinazolin-4(3H)-Ones
    Dawood, Nadia T. A.
    Abdel-Ghaffar, Nahed F.
    Soliman, Fekria M. A.
    EGYPTIAN JOURNAL OF CHEMISTRY, 2011, 54 (01): : 1 - 15
  • [4] Design, Synthesis, Antiviral and Cytotoxicity Studies of Some 2-Phenyl-3-substituted quinazolin-4-(3H)-ones
    Saravanan, Sakthi
    Selvam, Periyasamy
    Lakra, Dhani Ram
    De Clercq, E.
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (01) : 260 - 264
  • [5] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW 2-ARYLOXYMETHYL-3-SUBSTITUTED-QUINAZOLIN-4(3H)-ONES
    KHAN, A
    SAKSENA, RK
    PHARMAZIE, 1988, 43 (12): : 864 - 865
  • [6] Facile synthesis of substituted quinazolin-4-(3H)-ones using low-valence titanium reagent
    Shi, DQ
    Rong, LC
    Wang, JX
    Zhuang, QY
    Wang, XS
    Hu, HW
    SYNTHETIC COMMUNICATIONS, 2004, 34 (10) : 1759 - 1765
  • [7] Synthesis of 2,3-disbustituted benzo[h] quinazolin-4-(3H)-ones
    Mamatha, M
    Reddy, MS
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2003, 13 (01) : 75 - 76
  • [8] Synthesis and anticancer activity of some novel 3(1,3,4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones
    Joseph, Alex
    Pai, Aravinda
    Srinivasan, K. K.
    Kedar, Tukaram
    Thomas, Angel Treasa
    Jessy, E. M.
    Singla, Rajeev K.
    ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY, 2010, 2 (02): : 158 - 167
  • [9] Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-butyl-3-substituted quinazolin-4-(3H)-ones
    Alagarsamy, V
    Rajasolomon, V
    Meena, R
    Ramseshu, KV
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (06) : 1091 - 1094
  • [10] Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones
    Alagarsamy, V
    Rajesh, R
    Ramaseshu, M
    Vijaykumar, S
    Ramseshu, KV
    Duraianandakumar, T
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2004, 27 (05) : 652 - 656
12345