SYNTHESIS AND STRUCTURE ELUCIDATION OF BENZOTHIAZOLE-CONTAINING COMPOUNDS FOR ANTIMICROBIAL INVESTIGATION

被引:0
|
作者
GHONEIM, KM [1 ]
ELBASIL, S [1 ]
OSMAN, AN [1 ]
SAID, MM [1 ]
MEGAHED, SA [1 ]
机构
[1] UNIV CAIRO,FAC PHARM,DEPT MICROBIOL,CAIRO,EGYPT
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暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Attempted cycloaddition of benzimidazole-2-thiol with arylidenemalononitriles 1 was unsuccessful. 2-Cyanomethyl-1,3-benzothiazole 6 condensed with certain aromatic aldehydes to produce 7, cycloaddition of which with cyanoacethydrazide 3 yielded B. Structure of the newly synthesized compounds was substantiated by spectroscopic data and/or unambiguous synthesis. Representative compounds were screened for antimicrobial activity.
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页码:1355 / 1361
页数:7
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