AUTOANTIBODIES AGAINST FORSSMAN GLYCOLIPIDS IN GRAVES-DISEASE AND HASHIMOTO THYROIDITIS

被引：0
|
作者：
ARIGA, T [1 ]
YOSHIDA, T [1 ]
MIMORI, T [1 ]
YU, RK [1 ]
机构：
[1] KEIO UNIV,SCH MED,DEPT MED,SHINJUKU KU,TOKYO 108,JAPAN
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1991年 / 86卷 / 03期
关键词：
AUTOIMMUNE DISEASE; GRAVES DISEASE; HASHIMOTO DISEASE; AUTOANTIBODIES; FORSSMAN GLYCOLIPID;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sera from patients with Graves' disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin-layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves' disease. A MoAb, TRMo-4, reacted strongly and specifically with Gb5. These results suggest that anti-Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti-Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.
引用
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页码：483 / 488
页数：6
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