AUTOANTIBODIES AGAINST FORSSMAN GLYCOLIPIDS IN GRAVES-DISEASE AND HASHIMOTO THYROIDITIS

被引：0

作者：

ARIGA, T ^{[1
]}

YOSHIDA, T ^{[1
]}

MIMORI, T ^{[1
]}

YU, RK ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT MED,SHINJUKU KU,TOKYO 108,JAPAN

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1991年 / 86卷 / 03期

关键词：

AUTOIMMUNE DISEASE; GRAVES DISEASE; HASHIMOTO DISEASE; AUTOANTIBODIES; FORSSMAN GLYCOLIPID;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sera from patients with Graves' disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin-layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves' disease. A MoAb, TRMo-4, reacted strongly and specifically with Gb5. These results suggest that anti-Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti-Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.

引用

页码：483 / 488

页数：6

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