SYNTHESIS OF 2',3'-DIDEOXY-3',4'-DIHYDROXYMETHYL SUBSTITUTED PYRIMIDINE NUCLEOSIDE ANALOGS

被引：3
|
作者：
BJORSNE, M
CLASSON, B
KERS, I
SAMUELSSON, B
KVARNSTROM, I
机构：
[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN
[2] LINKOPING UNIV,DEPT CHEM,S-43183 LINKOPING,SWEDEN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期
关键词：
D O I：
10.1016/0960-894X(94)00454-N
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some 2′,3′-dideoxy-3′,4′-dihydroxymethyl nucleoside analogues have been synthesised using an aldol condensation followed by in situ cross Canizzaro reduction in order to introduce the 4′-hydroxymethyl group. Glycosylation using silylated pyrimidine bases furnished the 2′,3′-dideoxy-3′,4′-dihydroxymethyl nucleoside analogues. © 1994.
引用
收藏
页码：43 / 46
页数：4
相关论文
共 50 条
  • [31] NUCLEOSIDES AND NUCLEOTIDES .125. SYNTHESIS AND BIOLOGICAL EVALUATION OF 2',3'-DIDEOXY-3'-FLUORO-2'-METHYLIDENE PYRIMIDINE NUCLEOSIDES
    HASSAN, AEA
    SHUTO, S
    MATSUDA, A
    NUCLEOSIDES & NUCLEOTIDES, 1994, 13 (1-3): : 197 - 211
  • [32] Synthesis and antiviral evaluation of 4'-hydroxymethyl-2',3'-dideoxy-3'thianucleosides and their cyclic monophosphates
    Chao, Q
    Nair, V
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (09) : 1199 - 1202
  • [33] CRYSTAL-STRUCTURE OF A NUCLEOSIDE ANALOG - 2',3'-DIDEOXY-3'-FLUORO-5-BROMOCYTIDINE
    DAS, AK
    MAZUMDAR, SK
    BERTOLASI, V
    VANAERSCHOT, A
    JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH, 1993, 23 (05): : 353 - 357
  • [34] Synthesis and biological evaluation of polyaminated 2′,3′-dideoxy-3′-thiacytidine prodrugs
    Camplo, M
    Mourier, N
    Chermann, JC
    Kraus, JL
    NUCLEOSIDES & NUCLEOTIDES, 1999, 18 (4-5): : 879 - 880
  • [35] SYNTHESIS OF 2',3'-DIDEOXY-3'-C-(HYDROXYMETHYL)-4'-THIONUCLEOSIDES AS POTENTIAL INHIBITORS OF HIV
    BRANALT, J
    KVARNSTROM, I
    NIKLASSON, G
    SVENSSON, SCT
    CLASSON, B
    SAMUELSSON, B
    JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (07): : 1783 - 1788
  • [36] Synthesis and anti-HIV evaluation of new 5-substituted-2',3'-dideoxy-3'-thiauridine nucleosides
    Mourier, N
    Trabaud, C
    Niddam, V
    Graciet, J
    Camplo, M
    Chermann, JC
    Kraus, JL
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1996, 15 (7-8): : 1397 - 1409
  • [37] CRYSTAL-STRUCTURE OF A NUCLEOSIDE ANALOG, 2',3'-DIDEOXY-3'-AZIDO-5-CHLOROCYTIDINE
    DAS, AK
    MAZUMDAR, SK
    BERTOLASI, V
    VANAERSCHOT, A
    JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH, 1993, 23 (05): : 437 - 440
  • [38] CRYSTAL-STRUCTURE OF A NUCLEOSIDE ANALOG, 2',3'-DIDEOXY-3'-FLUORO-5-CHLOROCYTIDINE
    DAS, AK
    MAZUMDAR, SK
    BERTOLASI, V
    VANAERSCHOT, A
    JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH, 1993, 23 (06): : 455 - 458
  • [39] Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks
    Rajagopalan, P
    Boudinot, FD
    Chu, CK
    Tennant, BC
    Baldwin, BH
    Schinazi, RF
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (03) : 642 - 645
  • [40] NEW SYNTHESIS OF 2',3'-DIDEOXY-3'-C-CYANO-2'-SUBSTITUTED THYMIDINES BY MICHAEL ADDITION-REACTIONS
    WU, JC
    CHATTOPADHYAYA, J
    TETRAHEDRON, 1989, 45 (03) : 855 - 862
12345