Synthesis and biological evaluation of polyaminated 2′,3′-dideoxy-3′-thiacytidine prodrugs

被引：2
|
作者：
Camplo, M
Mourier, N
Chermann, JC
Kraus, JL
机构：
[1] Univ Mediterrannee, Fac Sci Luminy, INSERM, U322,Lab Chim Biomol, F-13288 Marseille 9, France
[2] INSERM, Retrovirus & Maladies Assoc U322, F-13273 Marseille, France
来源：
NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期
关键词：
D O I：
10.1080/15257779908041590
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The syntheses and biological evaluation of polyaminated 2',3'-dideoxy-3'-thiacytidine have been performed. A new lead was found to increase the in vitro antiviral potency (syncitia formation on MT-4 cell line) of two order magnitude greater than the parent nucleoside drug. Moreover, the in vitro activity on HIV macrophages was found to be more than 3 log greater than the activity of the parent drug 1.
引用
收藏
页码：879 / 880
页数：2
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