Synthesis and biological evaluation of polyaminated 2′,3′-dideoxy-3′-thiacytidine prodrugs

被引：2

作者：

Camplo, M

Mourier, N

Chermann, JC

Kraus, JL

机构：

[1] Univ Mediterrannee, Fac Sci Luminy, INSERM, U322,Lab Chim Biomol, F-13288 Marseille 9, France

[2] INSERM, Retrovirus & Maladies Assoc U322, F-13273 Marseille, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041590

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The syntheses and biological evaluation of polyaminated 2',3'-dideoxy-3'-thiacytidine have been performed. A new lead was found to increase the in vitro antiviral potency (syncitia formation on MT-4 cell line) of two order magnitude greater than the parent nucleoside drug. Moreover, the in vitro activity on HIV macrophages was found to be more than 3 log greater than the activity of the parent drug 1.

引用

页码：879 / 880

页数：2

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