SYNTHESIS OF 2',3'-DIDEOXY-3',4'-DIHYDROXYMETHYL SUBSTITUTED PYRIMIDINE NUCLEOSIDE ANALOGS

被引：3
|
作者：
BJORSNE, M
CLASSON, B
KERS, I
SAMUELSSON, B
KVARNSTROM, I
机构：
[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN
[2] LINKOPING UNIV,DEPT CHEM,S-43183 LINKOPING,SWEDEN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期
关键词：
D O I：
10.1016/0960-894X(94)00454-N
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some 2′,3′-dideoxy-3′,4′-dihydroxymethyl nucleoside analogues have been synthesised using an aldol condensation followed by in situ cross Canizzaro reduction in order to introduce the 4′-hydroxymethyl group. Glycosylation using silylated pyrimidine bases furnished the 2′,3′-dideoxy-3′,4′-dihydroxymethyl nucleoside analogues. © 1994.
引用
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页码：43 / 46
页数：4
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