Imaging the biogenesis of individual HIV-1 virions in live cells

被引：0

作者：

Nolwenn Jouvenet

Paul D. Bieniasz

Sanford M. Simon

机构：

[1] Aaron Diamond AIDS Research Center,

[2] ,undefined

[3] Laboratory of Retrovirology,undefined

[4] and,undefined

[5] ,undefined

[6] Laboratory of Cellular Biophysics,undefined

[7] The Rockefeller University,undefined

[8] New York,undefined

[9] New York 10065,undefined

[10] USA,undefined

来源：

Nature | 2008年 / 454卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

For the first time, the assembly of a virus particle has been observed directly in live cells. Using techniques based on total internal reflection fluorescence microscopy, and live HeLa cells expressing fluorescent protein-tagged derivatives of Gag, the major structural component of HIV-1, individual HIV-1 virus particles were observed in real time. The resulting movies resolve a controversy over where in the cells HIV-1 assembly occurs — the virions appear individually at the plasma membrane and are assembled in about 5 or 6 minutes.

引用

页码：236 / 240

页数：4

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