Salicylate protects against MPTP-induced impairments in dopaminergic neurotransmission at the striatal and nigral level in mice

被引：0

作者：

B. Ferger

P. Teismann

C.D. Earl

K. Kuschinsky

W.H. Oertel

机构：

[1] Institut für Pharmakologie und Toxikologie,

[2] Fachbereich Pharmazie,undefined

[3] Philipps-Universität Marburg,undefined

[4] Ketzerbach 63,undefined

[5] D-35032 Marburg,undefined

[6] Medizinisches Zentrum für Nervenheilkunde,undefined

[7] Klinik für Neurologie,undefined

[8] Philipps-Universität Marburg,undefined

[9] Rudolf-Bultmann-Strasse 8,undefined

[10] D-35033 Marburg,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 1999年 / 360卷

关键词：

Salicylic acid Hydroxyl radicals 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinson's disease Radical scavenger Neuroprotection;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The analgesic and anti-inflammatory drug sodium salicylate was studied for its potential protective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. C 57BL/6 mice were treated with a single dose of sodium salicylate (50 mg/kg or 100 mg/kg i.p.) or saline immediately before injection of MPTP (30 mg/kg or 40 mg/kg s.c.) or saline. Analysis of striatal dopamine and metabolites as well as immunostaining for tyrosine hydroxylase of nigral sections was performed 7 days after MPTP treatment.

引用

页码：256 / 261

页数：5

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