Salicylate protects against MPTP-induced impairments in dopaminergic neurotransmission at the striatal and nigral level in mice

被引：0

作者：

B. Ferger

P. Teismann

C.D. Earl

K. Kuschinsky

W.H. Oertel

机构：

[1] Institut für Pharmakologie und Toxikologie,

[2] Fachbereich Pharmazie,undefined

[3] Philipps-Universität Marburg,undefined

[4] Ketzerbach 63,undefined

[5] D-35032 Marburg,undefined

[6] Medizinisches Zentrum für Nervenheilkunde,undefined

[7] Klinik für Neurologie,undefined

[8] Philipps-Universität Marburg,undefined

[9] Rudolf-Bultmann-Strasse 8,undefined

[10] D-35033 Marburg,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 1999年 / 360卷

关键词：

Salicylic acid Hydroxyl radicals 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinson's disease Radical scavenger Neuroprotection;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The analgesic and anti-inflammatory drug sodium salicylate was studied for its potential protective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. C 57BL/6 mice were treated with a single dose of sodium salicylate (50 mg/kg or 100 mg/kg i.p.) or saline immediately before injection of MPTP (30 mg/kg or 40 mg/kg s.c.) or saline. Analysis of striatal dopamine and metabolites as well as immunostaining for tyrosine hydroxylase of nigral sections was performed 7 days after MPTP treatment.

引用

页码：256 / 261

页数：5

共 50 条

[21] Melatonin is protective against MPTP-induced striatal and hippocampal lesions
AcunaCastroviejo, D
CotoMontes, A
Monti, MG
Ortiz, GG
Reiter, RJ
LIFE SCIENCES, 1996, 60 (02) : PL23 - PL29
[22] SODIUM DIETHYLDITHIOCARBAMATE PROTECTS AGAINST THE MPTP-INDUCED INHIBITION OF IMMUNE-RESPONSES IN MICE
RENOUX, G
BIZIERE, K
RENOUX, M
STEINBERG, R
KAN, JP
GUILLAUMIN, JM
LIFE SCIENCES, 1989, 44 (12) : 771 - 777
[23] The α7 nAChR Agonist PNU-282987 Reduces Inflammation and MPTP-Induced Nigral Dopaminergic Cell Loss in Mice
Stuckenholz, Vanessa
Bacher, Michael
Balzer-Geldsetzer, Monika
Alvarez-Fischer, Daniel
Oertel, Wolfgang H.
Dodel, Richard C.
Noelker, Carmen
JOURNAL OF PARKINSONS DISEASE, 2013, 3 (02) : 161 - 172
[24] Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration
Budge, Kevin M.
Neal, Matthew L.
Richardson, Jason R.
Safadi, Fayez F.
MOLECULAR NEUROBIOLOGY, 2020, 57 (07) : 2920 - 2933
[25] Heme oxygenase-1 protects MPTP-induced dopaminergic neuronal death
Han, Ho-Kyun
Bae, Jung-Woo
Jang, Choon-Gon
Lee, Hwan-Joo
Jung, Dong-Won
Lee, Seok-Yong
ACTA PHARMACOLOGICA SINICA, 2006, 27 : 109 - 109
[26] Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration
Kevin M. Budge
Matthew L. Neal
Jason R. Richardson
Fayez F. Safadi
Molecular Neurobiology, 2020, 57 : 2920 - 2933
[27] Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration
Budge, Kevin
Neal, Matthew
Richardson, Jason
Safadi, Fayez
FASEB JOURNAL, 2019, 33
[28] AMPHETAMINE, BUT NOT RESERPINE, PROTECTS MICE AGAINST DOPAMINERGIC NEUROTOXICITY OF MPTP
MELAMED, E
ROSENTHAL, J
COHEN, O
UZZAN, A
GLOBUS, M
NEUROPHARMACOLOGY, 1985, 24 (09) : 923 - 925
[29] NORADRENALINE DEPLETION EXACERBATES MPTP-INDUCED STRIATAL DOPAMINE LOSS IN MICE
MARIEN, M
BRILEY, M
COLPAERT, F
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 236 (03) : 487 - 489
[30] Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice
Boireau, A
Bordier, F
Dubedat, P
Peny, C
Imperato, A
NEUROSCIENCE LETTERS, 1997, 234 (2-3) : 123 - 126

← 1 2 3 4 5 →