Salicylate protects against MPTP-induced impairments in dopaminergic neurotransmission at the striatal and nigral level in mice

被引：0

作者：

B. Ferger

P. Teismann

C.D. Earl

K. Kuschinsky

W.H. Oertel

机构：

[1] Institut für Pharmakologie und Toxikologie,

[2] Fachbereich Pharmazie,undefined

[3] Philipps-Universität Marburg,undefined

[4] Ketzerbach 63,undefined

[5] D-35032 Marburg,undefined

[6] Medizinisches Zentrum für Nervenheilkunde,undefined

[7] Klinik für Neurologie,undefined

[8] Philipps-Universität Marburg,undefined

[9] Rudolf-Bultmann-Strasse 8,undefined

[10] D-35033 Marburg,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 1999年 / 360卷

关键词：

Salicylic acid Hydroxyl radicals 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinson's disease Radical scavenger Neuroprotection;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The analgesic and anti-inflammatory drug sodium salicylate was studied for its potential protective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. C 57BL/6 mice were treated with a single dose of sodium salicylate (50 mg/kg or 100 mg/kg i.p.) or saline immediately before injection of MPTP (30 mg/kg or 40 mg/kg s.c.) or saline. Analysis of striatal dopamine and metabolites as well as immunostaining for tyrosine hydroxylase of nigral sections was performed 7 days after MPTP treatment.

引用

页码：256 / 261

页数：5

共 50 条

[11] Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice
Shen, HY
He, JC
Wang, YM
Huang, QY
Chen, JF
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (48) : 39962 - 39969
[12] Prevention of MPTP-induced parkinsonism by calbindin recruitment into nigral dopaminergic cells
Inoue, Kenichi
Miyachi, Shigehiro
Nishi, Katsunon
Okado, Haruo
Nambu, Atsushi
Takada, Masahiko
NEUROSCIENCE RESEARCH, 2009, 65 : S246 - S246
[13] Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway
Pan, Jing
Qian, Jing
Zhang, Yu
Ma, Jianfang
Wang, Gang
Xiao, Qin
Chen, Shengdi
Ding, Jianqing
LABORATORY INVESTIGATION, 2010, 90 (02) : 156 - 167
[14] Riluzole protects against MPTP-induced dopamine and DOPAC depletion in mice
Kumagai, T
Ido, T
Araki, T
Matsubara, M
Imai, Y
BIOGENIC AMINES, 2001, 16 (02) : 157 - 172
[15] MPTP-induced parkinsonism in mice alters striatal and nigral xCT expression but is unaffected by the genetic loss of xCT
Bentea, Eduard
Sconce, Michelle D.
Churchill, Madeline J.
Van Liefferinge, Joeri
Sato, Hideyo
Meshul, Charles K.
Massie, Ann
NEUROSCIENCE LETTERS, 2015, 593 : 1 - 6
[16] Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain
Pu, Yaoyu
Chang, Lijia
Qu, Youge
Wang, Siming
Zhang, Kai
Hashimoto, Kenji
AGING-US, 2019, 11 (17): : 6915 - 6929
[17] Effects of cysteamine on MPTP-induced dopaminergic neurodegeneration in mice
Sun, Linjuan
Xu, Shengli
Zhou, Ming
Wang, Chaodong
Wu, Yanchuan
Chan, Piu
BRAIN RESEARCH, 2010, 1335 : 74 - 82
[18] Batryticatus Bombyx Protects Dopaminergic Neurons against MPTP-Induced Neurotoxicity by Inhibiting Oxidative Damage
Lim, Hye-Sun
Kim, Joong-Sun
Moon, Byeong Cheol
Ryu, Seung Mok
Lee, Jun
Park, Gunhyuk
ANTIOXIDANTS, 2019, 8 (12)
[19] Complement 3-deficient mice are not protected against MPTP-induced dopaminergic neurotoxicity
Liang, Yajie
Li, Shurong
Guo, Qiang
Zhang, Yanliang
Wen, Can
Zou, Qiang
Su, Bingyin
BRAIN RESEARCH, 2007, 1178 : 132 - 140
[20] Ethylenebisdithiocarbamate enhances MPTP-induced striatal dopamine depletion in mice
McGrew, DM
Irwin, I
Langston, JW
NEUROTOXICOLOGY, 2000, 21 (03) : 309 - 312

← 1 2 3 4 5 →