Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection

被引：0
|
作者：
Selvin Noé Palacios-Rápalo
Luis Adrián De Jesús-González
José Manuel Reyes-Ruiz
Juan Fidel Osuna-Ramos
Carlos Noe Farfan-Morales
Ana Lorena Gutiérrez-Escolano
Rosa María del Ángel
机构：
[1] Department of Infectomics and Molecular Pathogenesis,
[2] Center for Research and Advanced Studies (CINVESTAV-IPN),undefined
来源：
Archives of Virology | 2021年 / 166卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although dengue virus (DENV) replication occurs in the cytoplasm, the nucleus plays an essential role during infection. Both the capsid protein (C) and non-structural protein 5 (NS5) are translocated into the infected cell nucleus to favor viral replication. Previously, our group reported the nuclear localization of the NS3 protein during DENV infection of mosquito cells; however, the nuclear localization of the DENV NS3 protein in human host cells has not been described. Here, we demonstrated that NS3 is present in the nucleus of Huh7 cells at early infection times, and later, it is mainly located in the cytoplasm.
引用
收藏
页码：1439 / 1446
页数：7
相关论文
共 50 条
  • [41] Recombinant dengue 2 virus NS3 protein conserves structural antigenic and immunological properties relevant for dengue vaccine design
    Ramirez, Rosa
    Falcon, Rosabel
    Izquierdo, Alienys
    Garcia, Angelica
    Alvarez, Mayling
    Beatriz Perez, Ana
    Soto, Yudira
    Mune, Mayra
    da Silva, Emiliana Mandarano
    Ortega, Oney
    Mohana-Borges, Ronaldo
    Guzman, Maria G.
    VIRUS GENES, 2014, 49 (02) : 185 - 195
  • [42] Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein
    Chua, JJE
    Bhuvanakantham, R
    Chow, VTK
    Ng, ML
    VIRUS RESEARCH, 2005, 112 (1-2) : 85 - 94
  • [43] Recombinant dengue 2 virus NS3 protein conserves structural antigenic and immunological properties relevant for dengue vaccine design
    Rosa Ramírez
    Rosabel Falcón
    Alienys Izquierdo
    Angélica García
    Mayling Alvarez
    Ana Beatriz Pérez
    Yudira Soto
    Mayra Muné
    Emiliana Mandarano da Silva
    Oney Ortega
    Ronaldo Mohana-Borges
    María G. Guzmán
    Virus Genes, 2014, 49 : 185 - 195
  • [44] Studies on the role of NS3 and NS5A non-structural genes of hepatitis C virus genotype 3a local isolates in apoptosis
    Sabri, Sabeen
    Idrees, Muhammad
    Rafique, Shazia
    Ali, Amjad
    Iqbal, Muhammad
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2014, 25 : 38 - 44
  • [45] Dengue virus protein NS3 activates hexokinase activity in hepatocytes to support virus replication
    Figl, Marianne
    Jacquemin, Clemence
    Perrin-Cocon, Laure
    Andre, Patrice
    Lotteau, Vincent
    Diaz, Olivier
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E805 - E806
  • [46] La protein binds to NS5 and NS3 and to the 5′ and 3′ ends of Dengue 4 virus RNA
    García-Montalvo, BM
    Medina, F
    del Angel, RM
    VIRUS RESEARCH, 2004, 102 (02) : 141 - 150
  • [47] BI-201335 Treatment of Hepatitis C Virus Serine Protease NS3/Non-Structural Protein 4A (NS4A) Inhibitor
    Vachon, Marie-Louise
    DRUGS OF THE FUTURE, 2012, 37 (02) : 99 - 109
  • [48] Nuclear localization of non-structural protein 1 and nucleocapsid protein of equine arteritis virus
    Tijms, MA
    van der Meer, Y
    Snijder, EJ
    JOURNAL OF GENERAL VIROLOGY, 2002, 83 : 795 - 800
  • [49] NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus
    Shiryaev, Sergey A.
    Chernov, Andrei V.
    Aleshin, Alexander E.
    Shiryaeva, Tatiana N.
    Strongin, Alex Y.
    JOURNAL OF GENERAL VIROLOGY, 2009, 90 : 2081 - 2085
  • [50] Mutagenesis of the NS3 protease of dengue virus type 2
    Valle, RPC
    Falgout, B
    JOURNAL OF VIROLOGY, 1998, 72 (01) : 624 - 632
12345