Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection

被引：0
|
作者：
Selvin Noé Palacios-Rápalo
Luis Adrián De Jesús-González
José Manuel Reyes-Ruiz
Juan Fidel Osuna-Ramos
Carlos Noe Farfan-Morales
Ana Lorena Gutiérrez-Escolano
Rosa María del Ángel
机构：
[1] Department of Infectomics and Molecular Pathogenesis,
[2] Center for Research and Advanced Studies (CINVESTAV-IPN),undefined
来源：
Archives of Virology | 2021年 / 166卷
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摘要：
Although dengue virus (DENV) replication occurs in the cytoplasm, the nucleus plays an essential role during infection. Both the capsid protein (C) and non-structural protein 5 (NS5) are translocated into the infected cell nucleus to favor viral replication. Previously, our group reported the nuclear localization of the NS3 protein during DENV infection of mosquito cells; however, the nuclear localization of the DENV NS3 protein in human host cells has not been described. Here, we demonstrated that NS3 is present in the nucleus of Huh7 cells at early infection times, and later, it is mainly located in the cytoplasm.
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页码：1439 / 1446
页数：7
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