Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection

被引：0
|
作者：
Selvin Noé Palacios-Rápalo
Luis Adrián De Jesús-González
José Manuel Reyes-Ruiz
Juan Fidel Osuna-Ramos
Carlos Noe Farfan-Morales
Ana Lorena Gutiérrez-Escolano
Rosa María del Ángel
机构：
[1] Department of Infectomics and Molecular Pathogenesis,
[2] Center for Research and Advanced Studies (CINVESTAV-IPN),undefined
来源：
Archives of Virology | 2021年 / 166卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although dengue virus (DENV) replication occurs in the cytoplasm, the nucleus plays an essential role during infection. Both the capsid protein (C) and non-structural protein 5 (NS5) are translocated into the infected cell nucleus to favor viral replication. Previously, our group reported the nuclear localization of the NS3 protein during DENV infection of mosquito cells; however, the nuclear localization of the DENV NS3 protein in human host cells has not been described. Here, we demonstrated that NS3 is present in the nucleus of Huh7 cells at early infection times, and later, it is mainly located in the cytoplasm.
引用
收藏
页码：1439 / 1446
页数：7
相关论文
共 50 条
  • [31] Hepatitis C virus non-structural protein (NS3) interacts with MAPK pathway JNK in HepG2 cells
    Hassan, M
    Erhardt, A
    Häussinger, D
    JOURNAL OF HEPATOLOGY, 2001, 34 : 25 - 25
  • [32] Refolding of a recombinant full-length non-structural (NS3) protein from hepatitis C virus by chromatographic procedures
    Ming Li
    Anton Poliakov
    U. Helena Danielson
    Zhiguo Su
    Jan-Christer Janson
    Biotechnology Letters, 2003, 25 : 1729 - 1734
  • [33] Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type I interferon signaling by targeting STAT1
    Li, Zhuoran
    Lu, Danfeng
    Yang, Heng
    Li, Zhuoyue
    Zhu, Pei
    Xie, Jiarui
    Liao, Defang
    Zheng, Yongtang
    Li, Huachun
    VETERINARY MICROBIOLOGY, 2021, 254
  • [34] Targeting the protease activity of Dengue virus NS3
    Yin, Zheng
    Lim, Siew Pheng
    Patel, Sejal
    Patel, Viral
    Beer, David
    Ma, Ngai Ling
    Vasudevan, Subhash
    Keller, Thomas
    ACTA PHARMACOLOGICA SINICA, 2006, 27 : 251 - 251
  • [35] MAb 4F5, Non-Structural Protein 3 of Dengue Virus
    Chen Zongtao
    HYBRIDOMA, 2008, 27 (06): : 503 - 504
  • [36] High Affinity Human Antibody Fragments to Dengue Virus Non-Structural Protein 3
    Moreland, Nicole J.
    Tay, Moon Y. F.
    Lim, Elfin
    Paradkar, Prasad N.
    Doan, Danny N. P.
    Yau, Yin Hoe
    Shochat, Susana Geifman
    Vasudevan, Subhash G.
    PLOS NEGLECTED TROPICAL DISEASES, 2010, 4 (11)
  • [37] Subcellular localization of the nonstructural protein NS3 of African horsesickness virus
    Stoltz, MA
    vanderMerwe, CF
    Coetzee, J
    Huismans, H
    ONDERSTEPOORT JOURNAL OF VETERINARY RESEARCH, 1996, 63 (01) : 57 - 61
  • [38] Genome segment reassortment identifies non-structural protein NS3 as a key protein in African horsesickness virus release and alteration of membrane permeability
    Tracy L. Meiring
    Henk Huismans
    Vida van Staden
    Archives of Virology, 2009, 154 : 263 - 271
  • [39] Genome segment reassortment identifies non-structural protein NS3 as a key protein in African horsesickness virus release and alteration of membrane permeability
    Meiring, Tracy L.
    Huismans, Henk
    van Staden, Vida
    ARCHIVES OF VIROLOGY, 2009, 154 (02) : 263 - 271
  • [40] Function and Mechanism of Hepatitis C Virus Non-Structural Protein 3 (HCV NS3) Unfolding of Viral G-quadruplex RNA Structures
    Belachew, Binyam Ateka
    Byrd, Alicia
    Gao, Jun
    Raney, Kevin
    FASEB JOURNAL, 2019, 33
12345