The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

被引：0
|
作者：
Dinis Pedro Calado
Yoshiteru Sasaki
Susana A Godinho
Alex Pellerin
Karl Köchert
Barry P Sleckman
Ignacio Moreno de Alborán
Martin Janz
Scott Rodig
Klaus Rajewsky
机构：
[1] Program of Cellular and Molecular Medicine,Department of Molecular and Cellular Physiology
[2] Children's Hospital,Department of Pediatric Oncology, Department of Cell Biology
[3] and Immune Disease Institute,Department of Pathology and Immunology
[4] Harvard Medical School,Department of Immunology and Oncology
[5] Max Delbrück Center for Molecular Medicine,Department of Pathology
[6] Graduate School of Medicine,undefined
[7] Kyoto University,undefined
[8] Dana-Farber Cancer Institute,undefined
[9] Harvard Medical School,undefined
[10] Washington University School of Medicine,undefined
[11] National Centre for Biotechnology,undefined
[12] Hematology,undefined
[13] Oncology and Tumor Immunology,undefined
[14] Charité,undefined
[15] University Medical School,undefined
[16] Brigham and Women's Hospital,undefined
来源：
Nature Immunology | 2012年 / 13卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The regulator c-Myc is well known for controlling cell growth but, paradoxically, evidence for its involvement in germinal centers has proven elusive. Rajewsky and colleagues show that it is essential for their development and maintenance.
引用
收藏
页码：1092 / 1100
页数：8
相关论文
共 50 条
  • [41] Stabilization of c-Myc by the atypical cell cycle regulator, Spy1, decreases efficacy of breast cancer treatments
    Rosa-Maria Ferraiuolo
    Bre-Anne Fifield
    Caroline Hamm
    Lisa A. Porter
    Breast Cancer Research and Treatment, 2022, 196 : 17 - 30
  • [42] COMPARATIVE-ANALYSIS OF THE INTRACELLULAR-LOCALIZATION OF C-MYC, C-FOS, AND REPLICATIVE PROTEINS DURING CELL-CYCLE PROGRESSION
    VRIZ, S
    LEMAITRE, JM
    LEIBOVICI, M
    THIERRY, N
    MECHALI, M
    MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (08) : 3548 - 3555
  • [43] C-MYC MESSENGER-RNA LEVELS IN THE CELL-CYCLE CHANGE IN MOUSE ERYTHROLEUKEMIA-CELLS FOLLOWING INDUCER TREATMENT
    LACHMAN, HM
    HATTON, KS
    SKOULTCHI, AI
    SCHILDKRAUT, CL
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (16) : 5323 - 5327
  • [44] A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc
    Liu, ZJ
    Ueda, T
    Miyazaki, T
    Tanaka, N
    Mine, S
    Tanaka, Y
    Taniguchi, T
    Yamamura, H
    Minami, Y
    MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (06) : 3445 - 3454
  • [45] c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
    Baena, E
    Gandarillas, A
    Vallespinós, M
    Zanet, J
    Bachs, O
    Redondo, C
    Fabregat, I
    Martinez, C
    de Alborán, IM
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (20) : 7286 - 7291
  • [46] CONSTITUTIVE C-MYC EXPRESSION IN AN IL-3-DEPENDENT MYELOID CELL-LINE SUPPRESSES CELL-CYCLE ARREST AND ACCELERATES APOPTOSIS
    ASKEW, DS
    ASHMUN, RA
    SIMMONS, BC
    CLEVELAND, JL
    ONCOGENE, 1991, 6 (10) : 1915 - 1922
  • [47] Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice
    Sheng, Yue
    Ma, Rui
    Yu, Chunjie
    Wu, Qiong
    Zhang, Steven
    Paulsen, Kimberly
    Zhang, Jiwang
    Ni, Hongyu
    Huang, Yong
    Zheng, Yi
    Qian, Zhijian
    BLOOD, 2021, 137 (05) : 610 - 623
  • [48] Nucleostemin: a multiplex regulator of cell-cycle progression
    Ma, Hanhui
    Pederson, Thoru
    TRENDS IN CELL BIOLOGY, 2008, 18 (12) : 575 - 579
  • [49] Alterations of cell cycle control and apoptosis during hepatic tumor progression in c-myc and c-myc/TGF alpha transgenic mice.
    SantoniRugiu, E
    Thorgeirsson, SS
    FASEB JOURNAL, 1997, 11 (03): : 1313 - 1313
  • [50] c-Myc transrepression and cell transformation
    Lee, LA
    Dang, CV
    C-MYC IN B-CELL NEOPLASIA: 14TH WORKSHOP ON MECHANISMS IN B-CELL NEOPLASIA, 1997, 224 : 131 - 135
12345