Two new sesquiterpenoid lactone derivatives from Lindera aggregata

被引：10

作者：

Wen, Song-Song ^{[1
,2
]}

Wang, Yan ^{[3
]}

Xu, Jia-Ping ^{[1
]}

Liu, Qi ^{[1
]}

Zhang, Lei ^{[1
]}

Zheng, Jing ^{[1
]}

Li, Lin ^{[1
]}

Zhang, Na ^{[2
]}

Liu, Xin ^{[4
]}

Xu, Yu-Wen ^{[1
]}

Sun, Zhen-Liang ^{[5
]}

机构：

[1] Shandong Res Ctr Engn & Technol Consistency Evalu, Shandong Inst Food & Drug Control, NMPA Key Lab Res & Evaluat Gener Drugs, Jinan, Peoples R China

[2] Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Minist Educ, Jinan, Peoples R China

[3] Shanghai Putuo Dist Liqun Hosp, Shanghai, Peoples R China

[4] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[5] Southern Med Univ, Affiliated Fengxian Hosp, Shanghai, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Lindera aggregata; sesquiterpenoid; electronic circular dichroism; anticoagulant; ALKALOIDS; ROOT;

D O I：

10.1080/14786419.2021.1939332

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new sesquiterpenoid lactone derivatives, linderin A (1) and linderin B (2) comprising a sesquiterpenoid lactone and a methyl geranylhomogentisate moiety together with six known compounds were isolated from the roots of Lindera aggregata. Their chemical structures were elucidated using extensive spectroscopic analysis including 1 D, 2 D NMR, and HR-ESI-MS data and compared with previously reported data. The absolute configurations of 1 and 2 were assigned based on the electronic circular dichroism calculation. Compound 2 showed moderate anticoagulant activity.

引用

页码：5407 / 5415

页数：9

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