Two new sesquiterpenoid lactone derivatives from Lindera aggregata

被引：10

作者：

Wen, Song-Song ^{[1
,2
]}

Wang, Yan ^{[3
]}

Xu, Jia-Ping ^{[1
]}

Liu, Qi ^{[1
]}

Zhang, Lei ^{[1
]}

Zheng, Jing ^{[1
]}

Li, Lin ^{[1
]}

Zhang, Na ^{[2
]}

Liu, Xin ^{[4
]}

Xu, Yu-Wen ^{[1
]}

Sun, Zhen-Liang ^{[5
]}

机构：

[1] Shandong Res Ctr Engn & Technol Consistency Evalu, Shandong Inst Food & Drug Control, NMPA Key Lab Res & Evaluat Gener Drugs, Jinan, Peoples R China

[2] Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Minist Educ, Jinan, Peoples R China

[3] Shanghai Putuo Dist Liqun Hosp, Shanghai, Peoples R China

[4] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[5] Southern Med Univ, Affiliated Fengxian Hosp, Shanghai, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Lindera aggregata; sesquiterpenoid; electronic circular dichroism; anticoagulant; ALKALOIDS; ROOT;

D O I：

10.1080/14786419.2021.1939332

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new sesquiterpenoid lactone derivatives, linderin A (1) and linderin B (2) comprising a sesquiterpenoid lactone and a methyl geranylhomogentisate moiety together with six known compounds were isolated from the roots of Lindera aggregata. Their chemical structures were elucidated using extensive spectroscopic analysis including 1 D, 2 D NMR, and HR-ESI-MS data and compared with previously reported data. The absolute configurations of 1 and 2 were assigned based on the electronic circular dichroism calculation. Compound 2 showed moderate anticoagulant activity.

引用

页码：5407 / 5415

页数：9

共 50 条

[11] Myrrhalindenane C, a New Eudesmane Sesquiterpenoid From Lindera Myrrha Roots
Hoang-Dung Nguyen
Huy Truong Nguyen
Thi-Hoai-Thu Nguyen
Sichaem, Jirapast
Huu-Hung Nguyen
Ngoc-Hong Nguyen
Thuc-Huy Duong
RECORDS OF NATURAL PRODUCTS, 2023, 17 (02) : 312 - 317
[12] A New Sesquiterpenoid-Geranylbenzene Conjugate from the Roots of Lindera chunii
Wen, Songsong
Li, Qiyang
Liu, Qi
Dou, Yanli
Niu, Chong
Xu, Yuwen
Zhang, Na
Wang, Weijian
CHEMISTRY OF NATURAL COMPOUNDS, 2022, 58 (06) : 1045 - 1047
[13] A New Sesquiterpenoid-Geranylbenzene Conjugate from the Roots of Lindera chunii
Songsong Wen
Qiyang Li
Qi Liu
Yanli Dou
Chong Niu
Yuwen Xu
Na Zhang
Weijian Wang
Chemistry of Natural Compounds, 2022, 58 : 1045 - 1047
[14] One new type proanthocyanidin trimer from Lindera aggregata (Sims) Kosterm
Zhang, CF
Sun, QS
Wang, ZT
Hattori, M
CHINESE CHEMICAL LETTERS, 2003, 14 (10) : 1033 - 1036
[15] A new eudesmane sesquiterpenoid lactone from Chloranthus japonicus
Fang Ping-Lei
Liu Hai-Yang
Zhong Hui-Min
CHINESE JOURNAL OF NATURAL MEDICINES, 2012, 10 (01): : 24 - 27
[16] Sesquiterpene Lactones from the Root Tubers of Lindera aggregata
Gan, Li-She
Zheng, Yun-Liang
Mo, Jian-Xia
Liu, Xin
Li, Xin-Hua
Zhou, Chang-Xin
JOURNAL OF NATURAL PRODUCTS, 2009, 72 (08): : 1497 - 1501
[17] Anti-inflammatory principles from Lindera aggregata
Kuo, Ping-Chung
Wu, Yi-Hung
Hung, Hsin-Yi
Lam, Sio-Hong
Ma, Guo-Hao
Kuo, Liang-Mou
Hwang, Tsong-Long
Kuo, Daih-Huang
Wu, Tian-Shung
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (13)
[18] Correction to: A New Sesquiterpenoid-Geranylbenzene Conjugate from the Roots of Lindera chunii
Songsong Wen
Qiyan Li
Qi Liu
Yanli Dou
Chong Niu
Yuwen Xu
Na Zhang
Weijian Wang
Chemistry of Natural Compounds, 2023, 59 : 205 - 205
[19] Chemical constituents from the roots of Lindera aggregata and their biological activities
Jun-Jie Yang
Yi Chen
Mei-Li Guo
Gui-Xin Chou
Journal of Natural Medicines, 2020, 74 : 441 - 447
[20] Chemical constituents from the roots of Lindera aggregata and their biological activities
Yang, Jun-Jie
Chen, Yi
Guo, Mei-Li
Chou, Gui-Xin
JOURNAL OF NATURAL MEDICINES, 2020, 74 (02) : 441 - 447

← 1 2 3 4 5 →