Linderaggrenolides A-N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata

被引：17
|
作者：
Liu, Xin [1 ]
Fu, Jing [1 ]
Yang, Ji [1 ]
Huang, Ancheng C. [2 ]
Li, Run-Feng [1 ]
Bai, Li-Ping [1 ]
Liu, Liang [1 ]
Jiang, Zhi-Hong [1 ]
Zhu, Guo-Yuan [1 ]
机构：
[1] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Guangdong Hong Kong Macao Joint Lab Resp Infect D, Macau 999078, Peoples R China
[2] Southern Univ Sci & Technol, Inst Plant & Food Sci, Dept Biol, Shenzhen 518055, Peoples R China
来源：
ACS OMEGA | 2021年 / 6卷 / 08期
关键词：
STRYCHNIFOLIA; LACTONES; RHIZOMES;
D O I：
10.1021/acsomega.0c06349
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Linderaggrenolides A-N (1-14), 14 new lindenane sesquiterpenoid dimers with oxygen bridges were isolated from the roots of Lindera aggregata. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis, with the absolute configurations established by empirical approaches, electronic circular dichroism calculations, and X-ray crystallography. Compounds 8 and 9 were found to exhibit significant transforming growth factor-beta inhibitory activity, with IC50 values of 25.91 and 21.52 mu M, respectively.
引用
收藏
页码：5898 / 5909
页数：12
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