Synthesis of symmetrical methylene-bridged imidazoheterocycles using DMSO as methylene source under metal-free conditions

被引：55
|
作者：
Liu, Ping [1 ]
Shen, Ziyan [1 ]
Yuan, Yao [1 ]
Sun, Peipei [1 ]
机构：
[1] Nanjing Normal Univ, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Coll Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 27期
基金：
中国国家自然科学基金;
关键词：
N-METHYLATION; CATALYZED CLEAVAGE; FACILE SYNTHESIS; OXIDATION; SULFENYLATION; FORMYLATION; AMINES; METHYLTHIOLATION; THIOCYANATION; COMPLEXES;
D O I：
10.1039/c6ob00977h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile H3PO4-promoted bridging methylenation of imidazopyridines or similar heterocycles has been described for the synthesis of symmetrical methylene-bridged imidazoheterocycles, in which DMSO was used as the carbon source. The reaction obtained good yields for most substrates with high C3-regioselectivity. This method also features metal-free, practicability and low cost.
引用
收藏
页码：6523 / 6530
页数：8
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