IDENTIFICATION OF POTENT DUAL OREXIN RECEPTOR ANTAGONISTS

被引：0

作者：

Coleman, Paul J. ^{[1
]}

Schreier, John D. ^{[1
]}

Cox, Christopher D. ^{[1
]}

Breslin, Michael J. ^{[1
]}

Whitman, David B. ^{[1
]}

Roecker, Anthony J. ^{[1
]}

Bogusky, Michael J. ^{[1
]}

Bednar, Rodney A. ^{[1
]}

Lemaire, Wei ^{[1
]}

Bruno, Joseph C. ^{[1
]}

Hartman, George D. ^{[1
]}

McGaughey, Georgia B. ^{[1
]}

Reiss, Duane R. ^{[2
]}

Harrell, C. Meacham ^{[2
]}

Doran, Scott M. ^{[2
]}

Garson, Susan L. ^{[2
]}

Kraus, Richard L. ^{[2
]}

Li, Yuxing ^{[2
]}

Prueksaritanont, Thomayant ^{[3
]}

Li, Chunze ^{[3
]}

Winrow, Christopher J. ^{[2
]}

Koblan, Kenneth S. ^{[2
]}

Renger, John J. ^{[2
]}

机构：

[1] Merck Res Labs, Dept Med Chem, West Point, PA USA

[2] Merck Res Labs, Dept Depress & Circadian Disorders, West Point, PA USA

[3] Merck Res Labs, Dept Drug Metab, West Point, PA USA

来源：

DRUGS OF THE FUTURE | 2009年 / 34卷

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：10 / 11

页数：2

共 50 条

[41] GPCR structure-based drug discovery: Identification of dual orexin antagonists and orexin-1 selective antagonists for the treatment of insomnia and addiction disorders
Christopher, John A.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
[42] Dual orexin receptor antagonists for insomnia in youth with neurodevelopmental disorders: a case series and review
Besterman, Aaron D.
Jeste, Shafali S.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2023, 32 (03) : 527 - 531
[43] Novel therapeutic class for insomnia treatment: Dual orexin receptor antagonists - it is worth to prescribe it?
Nogueira, J.
Ribeiro, R.
Mendes, S.
Gamito, A.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2019, 29 : S515 - S515
[44] Dual orexin receptor antagonists for insomnia in youth with neurodevelopmental disorders: a case series and review
Aaron D. Besterman
Shafali S. Jeste
European Child & Adolescent Psychiatry, 2023, 32 : 527 - 531
[45] Different doses of dual orexin receptor antagonists in primary insomnia: a Bayesian network analysis
Xue, Tao
Wu, Xin
Li, Jiaxuan
Chen, Shujun
Wang, Zilan
Tan, Xin
Wang, Zhong
Zhang, Jianguo
FRONTIERS IN PHARMACOLOGY, 2023, 14
[46] The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
Gotter, Anthony L.
Winrow, Christopher J.
Brunner, Joseph
Garson, Susan L.
Fox, Steven V.
Binns, Jacquelyn
Harrell, Charles M.
Cui, Donghui
Yee, Ka Lai
Stiteler, Mark
Stevens, Joanne
Savitz, Alan
Tannenbaum, Pamela L.
Tye, Spencer J.
McDonald, Terrence
Yao, Leon
Kuduk, Scott D.
Uslaner, Jason
Coleman, Paul J.
Renger, John J.
BMC NEUROSCIENCE, 2013, 14
[47] Differential sleep-promoting effects of dual orexin receptor antagonists and GABAAreceptor modulators
Anthony L Gotter
Susan L Garson
Joanne Stevens
Regina L Munden
Steven V Fox
Pamela L Tannenbaum
Lihang Yao
Scott D Kuduk
Terrence McDonald
Jason M Uslaner
Spencer J Tye
Paul J Coleman
Christopher J Winrow
John J Renger
BMC Neuroscience, 15
[48] Orexin receptor antagonists: a new treatment for insomnia?
Riemann, Dieter
Spiegelhalder, Kai
LANCET NEUROLOGY, 2014, 13 (05): : 441 - 443
[49] Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists
Fujimoto, Tatsuhiko
Kunitomo, Jun
Tomata, Yoshihide
Nishiyama, Keiji
Nakashima, Masato
Hirozane, Mariko
Yoshikubo, Shin-ichi
Hirai, Keisuke
Marui, Shogo
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (21) : 6414 - 6416
[50] Opportunities and perspectives for developing orexin receptor antagonists
Barnes, Nicholas M.
FRONTIERS IN NEUROSCIENCE, 2014, 8

← 1 2 3 4 5 →