IDENTIFICATION OF POTENT DUAL OREXIN RECEPTOR ANTAGONISTS

被引：0

作者：

Coleman, Paul J. ^{[1
]}

Schreier, John D. ^{[1
]}

Cox, Christopher D. ^{[1
]}

Breslin, Michael J. ^{[1
]}

Whitman, David B. ^{[1
]}

Roecker, Anthony J. ^{[1
]}

Bogusky, Michael J. ^{[1
]}

Bednar, Rodney A. ^{[1
]}

Lemaire, Wei ^{[1
]}

Bruno, Joseph C. ^{[1
]}

Hartman, George D. ^{[1
]}

McGaughey, Georgia B. ^{[1
]}

Reiss, Duane R. ^{[2
]}

Harrell, C. Meacham ^{[2
]}

Doran, Scott M. ^{[2
]}

Garson, Susan L. ^{[2
]}

Kraus, Richard L. ^{[2
]}

Li, Yuxing ^{[2
]}

Prueksaritanont, Thomayant ^{[3
]}

Li, Chunze ^{[3
]}

Winrow, Christopher J. ^{[2
]}

Koblan, Kenneth S. ^{[2
]}

Renger, John J. ^{[2
]}

机构：

[1] Merck Res Labs, Dept Med Chem, West Point, PA USA

[2] Merck Res Labs, Dept Depress & Circadian Disorders, West Point, PA USA

[3] Merck Res Labs, Dept Drug Metab, West Point, PA USA

来源：

DRUGS OF THE FUTURE | 2009年 / 34卷

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：10 / 11

页数：2

共 50 条

[21] Selective orexin receptor antagonists
Lebold, Terry P.
Bonaventure, Pascal
Shireman, Brock T.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (17) : 4761 - 4769
[22] Orexin Receptor Antagonists and Insomnia
Wu, Xin
Xue, Tao
Chen, Zhouqing
Wang, Zhong
Chen, Gang
CURRENT PSYCHIATRY REPORTS, 2022, 24 (10) : 509 - 521
[23] Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)
Behnke, Dirk
Cotesta, Simona
Hintermann, Samuel
Fendt, Markus
Gee, Christine E.
Jacobson, Laura H.
Laue, Grit
Meyer, Arndt
Wagner, Trixie
Badiger, Sangamesh
Chaudhari, Vinod
Chebrolu, Murali
Pandit, Chetan
Hoyer, Daniel
Betschart, Claudia
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (23) : 5555 - 5560
[24] Orexin, orexin receptor antagonists and central cardiovascular control
Carrive, Pascal
FRONTIERS IN NEUROSCIENCE, 2013, 7
[25] Identification of potent, highly constrained CGRP receptor antagonists
Stump, Craig A.
Bell, Ian M.
Bednar, Rodney A.
Fay, John F.
Gallicchio, Steven N.
Hershey, James C.
Jelley, Richard
Kreatsoulas, Constantine
Moore, Eric L.
Mosser, Scott D.
Quigley, Amy G.
Roller, Shane A.
Salvatore, Christopher A.
Sharik, Steven S.
Theberge, Cory R.
Zartman, C. Blair
Kane, Stefanie A.
Graham, Samuel L.
Selnick, Harold G.
Vacca, Joseph P.
Williams, Theresa M.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (08) : 2572 - 2576
[26] The orexin story and orexin receptor antagonists for the treatment of insomnia
Muehlan, Clemens
Roch, Catherine
Vaillant, Cedric
Dingemanse, Jasper
JOURNAL OF SLEEP RESEARCH, 2023, 32 (06)
[27] Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists
Fujimoto, Tatsuhiko
Tomata, Yoshihide
Kunitomo, Jun
Hirozane, Mariko
Marui, Shogo
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (21) : 6409 - 6413
[28] Daridorexant, a Recently Approved Dual Orexin Receptor Antagonists (DORA) in Treatment of Insomnia
Chakraborty, Dwaipayan Sarathi
Choudhury, Shouvik
Lahiry, Sandeep
SLEEP SCIENCE, 2023, 16 (02) : 256 - 264
[29] Safety of dual orexin receptor antagonists: a real-world pharmacovigilance study
Sun, Yu
Xu, Tao
Xu, Hongbin
EXPERT OPINION ON DRUG SAFETY, 2025,
[30] Dual orexin receptor antagonists increase sleep and cataplexy in wild type mice
Mahoney, Carrie E.
Mochizuki, Takatoshi
Scammell, Thomas E.
SLEEP, 2020, 43 (06) : 1 - 17

← 1 2 3 4 5 →