A paclitaxel analogue with a 2(3→20)abeotaxane skeleton:: Synthesis and biological evaluation

被引：5
|
作者：
Soto, J
Mascareñas, JL
Castedo, L [1 ]
机构：
[1] Univ Santiago de Compostela, Fac Quim, Dept Quim Organ, Santiago De Compostela 15706, Spain
[2] CSIC, Santiago De Compostela 15706, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0960-894X(98)00005-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A paclitaxel analogue having an unusual tricyclic [9.3.1.1] hexadecane skeleton was synthesized from deaminoacyltaxine A, a 2(3-->20) abeotaxane isolated in considerable amounts from the leaves of Tarus baccata L. In preliminary studies, this compound showed a much lower cytotoxicity than paclitaxel. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：273 / 276
页数：4
相关论文
共 50 条
  • [41] SYNTHESIS AND BIOLOGICAL EVALUATION OF PACLITAXEL ANALOGS MODIFIED IN RING-C
    LIANG, XA
    KINGSTON, DGI
    LIN, CM
    HAMEL, E
    TETRAHEDRON LETTERS, 1995, 36 (17) : 2901 - 2904
  • [42] Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono)indolin-2-ones as anticancer agents
    Dweedar, Haytham E.
    Mahrous, Hoda
    Ibrahim, Hany S.
    Abdel-Aziz, Hatem A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 78 : 275 - 280
  • [43] Design, synthesis and biological evaluation of novel hydroxamic acids bearing artemisinin skeleton
    Vu Thi Ha
    Vu Tuan Kien
    Le Huy Binh
    Vu Dinh Tien
    Nguyen Thi Thuy My
    Nguyen Hai Nam
    Baltas, Michael
    Hahn, Hyunggu
    Han, Byung Woo
    Do Thi Thao
    Tran Khac Vu
    BIOORGANIC CHEMISTRY, 2016, 66 : 63 - 71
  • [44] A novel synthesis of benzo[c]phenanthridine skeleton and biological evaluation of isoquinoline derivatives
    Cho, WJ
    Park, MJ
    Imanishi, T
    Chung, BH
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1999, 47 (06) : 900 - 902
  • [45] Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents
    Lv, Peng-Cheng
    Li, Huan-Qiu
    Sun, Juan
    Zhou, Yang
    Zhu, Hai-Liang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (13) : 4606 - 4614
  • [46] Structure-activity relationships study at the 3′-N position of paclitaxel -: Part 1:: Synthesis and biological evaluation of the 3′-(t)-butylaminocarbonyloxy bearing paclitaxel analogs
    Chen, SH
    Xue, M
    Huang, S
    Long, BH
    Fairchild, CA
    Rose, WC
    Kadow, JF
    Vyas, D
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (23) : 3057 - 3062
  • [47] Structure-activity relationships study at the 3′-N position of paclitaxel.: Part 2:: Synthesis and biological evaluation of 3′-N-thiourea- and 3′-N-thiocarbamate-bearing paclitaxel analogues
    Xue, M
    Long, BH
    Fairchild, C
    Johnston, K
    Rose, WC
    Kadow, JF
    Vyas, DM
    Chen, SH
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (12) : 1327 - 1331
  • [48] Evaluation of the bioactive tubuilin-binding paclitaxel conformation:: Synthesis and biological evaluation of C4 to C3′-phenyl bridged paclitaxel analogs.
    Ganesh, T
    Bane, S
    Ravindra, R
    Shanker, N
    Lakdawala, AS
    Snyder, JP
    Norris, A
    Kingston, DGI
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U193 - U193
  • [49] Synthesis and biological evaluation of vioprolide B and its dehydrobutyrine-glycine analogue
    Reineke, Noe Osorio
    Elsen, Franziska A. V.
    Grab, Hanusch A.
    Mostert, Dietrich
    Sieber, Stephan A.
    Bach, Thorsten
    CHEMICAL COMMUNICATIONS, 2024, 60 (63) : 8272 - 8275
  • [50] Design, Synthesis, and Biological Evaluation of an Antagonist-Bombesin Analogue as Targeting Vector
    Abd-Elgaliel, Wael R.
    Gallazzi, Fabio
    Garrison, Jered C.
    Rold, Tammy L.
    Sieckman, Gary L.
    Figueroa, Said Daibes
    Hoffman, Timothy J.
    Lever, Susan Z.
    BIOCONJUGATE CHEMISTRY, 2008, 19 (10) : 2040 - 2048
12345