A paclitaxel analogue with a 2(3→20)abeotaxane skeleton:: Synthesis and biological evaluation

被引：5
|
作者：
Soto, J
Mascareñas, JL
Castedo, L [1 ]
机构：
[1] Univ Santiago de Compostela, Fac Quim, Dept Quim Organ, Santiago De Compostela 15706, Spain
[2] CSIC, Santiago De Compostela 15706, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0960-894X(98)00005-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A paclitaxel analogue having an unusual tricyclic [9.3.1.1] hexadecane skeleton was synthesized from deaminoacyltaxine A, a 2(3-->20) abeotaxane isolated in considerable amounts from the leaves of Tarus baccata L. In preliminary studies, this compound showed a much lower cytotoxicity than paclitaxel. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：273 / 276
页数：4
相关论文
共 50 条
  • [31] Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide
    Kim, Sanghee
    Cho, Minjae
    Lee, Taeho
    Lee, Sukjin
    Min, Hye-Young
    Lee, Sang Kook
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (16) : 4584 - 4587
  • [32] Synthesis and Biological Evaluation of Analogue of Delavayin-C: A Cyclic Heptapeptide
    Shinde, Nirmala V.
    Himaja, M.
    Bhosale, S. K.
    Wagh, R. D.
    ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (02) : 996 - 1000
  • [33] Synthesis and Biological Evaluation of Reniochalistatins A-E and a Reniochalistatin E Analogue
    Zhou, Rong
    Sun, Yueguang
    Li, Hangbin
    Long, Weili
    Liao, Xiaojian
    Feng, Pengju
    Xu, Shihai
    CHEMMEDCHEM, 2018, 13 (20) : 2202 - 2207
  • [34] Synthesis and biological evaluation of a new benzofuran analogue of 8-HETE
    Caijo, F
    Mosset, P
    Gree, R
    Chomarat, P
    Audinot-Bouchez, V
    Boutin, J
    Renard, P
    Caignard, DH
    Dacquet, C
    LETTERS IN ORGANIC CHEMISTRY, 2006, 3 (02) : 103 - 106
  • [35] Synthesis, conformational analysis and biological evaluation of the lactam analogue of the cyclodepsipeptide apratoxin A
    Yin, Ruwen
    Zhang, Wei
    Liu, Guoyun
    Wu, Ping
    Lau, Choiwan
    Li, Yingxia
    TETRAHEDRON, 2016, 72 (27-28) : 3823 - 3831
  • [36] Synthesis and First Biological Evaluation of an Iron-Containing HETE Analogue
    Kausch-Busies, Nina
    Kater, Benjamin
    Neudoerfl, Joerg M.
    Prokop, Aram
    Schmalz, Hans-Guenther
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 2011 (06) : 1133 - 1139
  • [37] Structure-activity relationship study at the 3′-N-position of paclitaxel:: Synthesis and biological evaluation of 3′-N-acyl-paclitaxel analogues
    Roh, EJ
    Kim, D
    Lee, CO
    Choi, SU
    Song, CE
    BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (10) : 3145 - 3151
  • [38] Design, synthesis and biological evaluation of novel paclitaxel photoaffinity labels.
    Spletstoser, JT
    Flaherty, PT
    Georg, GI
    Himes, RH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U30 - U30
  • [39] Synthesis and biological evaluation of photoaffinity, fluorescent, and radiolabeled paclitaxel analogues.
    Flaherty, PT
    Liu, YB
    Georg, GI
    Himes, RH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 215 : U911 - U911
  • [40] Synthesis and biological evaluation of hydrolytically stable, bifunctional paclitaxel conjugates.
    Ballatore, C
    Aspland, SE
    Castillo, R
    Desharnais, J
    Eustaquio, T
    Smith, AB
    Castellino, AJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U194 - U194
12345