A paclitaxel analogue with a 2(3→20)abeotaxane skeleton:: Synthesis and biological evaluation

被引：5
|
作者：
Soto, J
Mascareñas, JL
Castedo, L [1 ]
机构：
[1] Univ Santiago de Compostela, Fac Quim, Dept Quim Organ, Santiago De Compostela 15706, Spain
[2] CSIC, Santiago De Compostela 15706, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0960-894X(98)00005-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A paclitaxel analogue having an unusual tricyclic [9.3.1.1] hexadecane skeleton was synthesized from deaminoacyltaxine A, a 2(3-->20) abeotaxane isolated in considerable amounts from the leaves of Tarus baccata L. In preliminary studies, this compound showed a much lower cytotoxicity than paclitaxel. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：273 / 276
页数：4
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