Pharmacological regulation of mitochondrial nitric oxide synthase

被引：0
|
作者：
Valdez, LB [1 ]
Arnaiz, SL [1 ]
Bustamante, J [1 ]
Alvarez, S [1 ]
Boveris, AD [1 ]
Navarro, A [1 ]
Boveris, A [1 ]
机构：
[1] Univ Buenos Aires, Sch Pharm & Biochem, Lab Free Radical Biol, Buenos Aires, DF, Argentina
来源：
XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL | 2002年
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The activity of mtNOS can be modulated pharmacologically. Chlorpromazine (one dose 10 mg/kg, 1h) inhibited 36-48% mitochondrial NO production, increased 25-38% O-2 uptake and did not modify the amount of mtNOS protein detected by Western blot. Enalapril (30 mg/kg/day, up to 15 d) increased NO production in kidney, liver and heart mitochondria. In kidney mitochondria, mtNOS activity was 5 times increased and mtNOS protein 125% increased.
引用
收藏
页码：649 / 652
页数：4
相关论文
共 50 条
  • [41] Regulation of the expression of inducible nitric oxide synthase
    Pautz, Andrea
    Art, Julia
    Hahn, Susanne
    Nowag, Sebastian
    Voss, Cornelia
    Kleinert, Hartmut
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2010, 23 (02): : 75 - 93
  • [42] Regulation of the expression of inducible nitric oxide synthase
    Kleinert, H
    Schwarz, PM
    Förstermann, U
    BIOLOGICAL CHEMISTRY, 2003, 384 (10-11) : 1343 - 1364
  • [43] Cytoskeletal regulation of endothelial nitric oxide synthase
    Laufs, U
    Liao, JK
    CIRCULATION, 1998, 98 (17) : 405 - 406
  • [44] Regulation of vascular nitric oxide synthase II
    Catravas, JD
    Zhang, H
    Teng, X
    VASCULAR ENDOTHELIUM: SOURCE AND TARGET OF INFLAMMATORY MEDIATORS, 2001, 330 : 188 - 210
  • [45] Cellular regulation of endothelial nitric oxide synthase
    Govers, R
    Rabelink, TJ
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 280 (02) : F193 - F206
  • [46] Regulation of inducible nitric oxide synthase in the retina
    Goureau, O
    Faure, V
    De Kozak, Y
    Behar-Cohen, F
    Dighiero, P
    Courtois, Y
    NITRIC OXIDE IN THE EYE, 2000, : 135 - 142
  • [47] The regulation and pharmacology of endothelial nitric oxide synthase
    Dudzinski, DM
    Igarashi, J
    Greif, D
    Michel, T
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2006, 46 : 235 - 276
  • [48] Regulation of macula densa nitric oxide synthase
    Komlosi, P
    Xie, Y
    Fintha, A
    Unlap, MT
    Kovacs, G
    Bell, PD
    FASEB JOURNAL, 2005, 19 (05): : A1140 - A1140
  • [49] Nitric oxide synthase production and nitric oxide regulation of preimplantation embryo development
    Tranguch, S
    Steuerwald, N
    Huet-Hudson, YA
    BIOLOGY OF REPRODUCTION, 2003, 68 (05) : 1538 - 1544
  • [50] Regulation of type III nitric oxide synthase gene expression by nitric oxide
    Millatt, LJ
    Ravichandran, LV
    Johns, RA
    FASEB JOURNAL, 1996, 10 (03): : 2519 - 2519
12345