Pharmacological regulation of mitochondrial nitric oxide synthase

被引：0

作者：

Valdez, LB ^{[1
]}

Arnaiz, SL ^{[1
]}

Bustamante, J ^{[1
]}

Alvarez, S ^{[1
]}

Boveris, AD ^{[1
]}

Navarro, A ^{[1
]}

Boveris, A ^{[1
]}

机构：

[1] Univ Buenos Aires, Sch Pharm & Biochem, Lab Free Radical Biol, Buenos Aires, DF, Argentina

来源：

XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL | 2002年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of mtNOS can be modulated pharmacologically. Chlorpromazine (one dose 10 mg/kg, 1h) inhibited 36-48% mitochondrial NO production, increased 25-38% O-2 uptake and did not modify the amount of mtNOS protein detected by Western blot. Enalapril (30 mg/kg/day, up to 15 d) increased NO production in kidney, liver and heart mitochondria. In kidney mitochondria, mtNOS activity was 5 times increased and mtNOS protein 125% increased.

引用

页码：649 / 652

页数：4

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