Synthesis of 1,2,4-triazole-3-thiols and their S-substituted derivatives

被引：11
|
作者：
Kochikyan, T. V. [1 ]
Samvelyan, M. A. [1 ]
Arutyunyan, V. S. [1 ]
Avetisyan, A. A. [1 ]
Tamazyan, R. A. [2 ]
Aivazyan, A. G. [2 ]
机构：
[1] Erevan State Univ, Yerevan 375025, Armenia
[2] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Mol Struct Res Ctr, Yerevan 375014, Armenia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 46卷 / 04期
关键词：
Benzyl Chloride; Anhydrous Potassium Carbonate; Carbazide; Phenoxymethyl; Carboxylic Acid Hydrazide;
D O I：
10.1134/S1070428010040184
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New 1,2,4-triazole-3-thiols were synthesized by reactions of the corresponding carboxylic acid hydrazides with isothiocyanates and subsequent cyclization of intermediate 1,4-substituted thiosemicarbazides. Alkylation of 1,2,4-triazole-3-thiols with benzyl chlorides and bromacetophenones gave only S-substituted derivatives.
引用
收藏
页码：551 / 555
页数：5
相关论文
共 50 条
  • [41] The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones
    Karpun, Yevhen
    Parchenko, Volodymyr
    Fotina, Tetiana
    Demianenko, Denys
    Fotin, Anatolii
    Nahornyi, Volodymyr
    Nahorna, Natalia
    PHARMACIA, 2021, 68 (04) : 797 - 804
  • [42] SYNTHESIS　OF　1-SUBSTITUTED　1H-1,2,4-TRIAZOLE　DERIVATIVES
    Yan Nian SHI
    Yang YANG
    Jian Xin FANG and Wen Shuo LU (Inst. of Elemento-Organic Chem.
    Chinese Chemical Letters, 1996, (05) : 407 - 410
  • [43] Synthesis of 1-substituted 1H-1,2,4-triazole derivatives
    Shi, YN
    Yang, Y
    Fang, JX
    Lu, WS
    CHINESE CHEMICAL LETTERS, 1996, 7 (05) : 407 - 410
  • [44] Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer
    Mioc, Marius
    Avram, Sorin
    Bercean, Vasile
    Kurunczi, Ludovic
    Ghiulai, Roxana M.
    Oprean, Camelia
    Coricovac, Dorina E.
    Dehelean, Cristina
    Mioc, Alexandra
    Balan-Porcarasu, Mihaela
    Tatu, Calin
    Soica, Codruta
    FRONTIERS IN CHEMISTRY, 2018, 6
  • [45] Synthesis of some new substituted 1,2,4-triazole and 1,3,4-thiadiazole and their derivatives
    Zamani, K
    Faghihi, K
    Sangi, MR
    Zolgharnein, J
    TURKISH JOURNAL OF CHEMISTRY, 2003, 27 (01): : 119 - 125
  • [46] Syntheses of some novel and symmetrical bis(4-amino-4H-1,2,4-triazole-3-thiols)
    Ebrahimi, Sattar
    Sayadi, Masoomeh
    JOURNAL OF SULFUR CHEMISTRY, 2012, 33 (06) : 647 - 652
  • [47] Synthesis and Anti-Inflammatory Properties of Substituted 5-(Tetrahydro-4-phenyl-2H-pyran-4-yl)-4H-1,2,4-triazole-3-thiols
    Zh. S. Arustamyan
    R. E. Margaryan
    A. A. Aghekyan
    G. A. Panosyan
    R. E. Muradyan
    A. E. Tumajyan
    Russian Journal of Organic Chemistry, 2021, 57 : 195 - 202
  • [48] Novel 3,5-Dimethylpyrazole-Linked 1,2,4-Triazole-3-thiols as Potent Antihyperglycemic Agents: Synthesis, Biological Evaluation, and In Silico Molecular Modelling Investigations
    Rouzi, Khouloud
    Mortada, Salma
    Hassan, Mubashir
    Alsalme, Ali
    Kloczkowski, Andrzej
    El Karbane, Miloud
    Bouatia, Mustapha
    Faouzi, My El Abbes
    Karrouchi, Khalid
    CHEMISTRYSELECT, 2024, 9 (37):
  • [49] Synthesis and Antimicrobial Activity of New Substituted Fused 1,2,4-Triazole Derivatives
    El-Sayed, Wael A.
    Ali, Omar M.
    Hathoot, Marwa M.
    Abdel-Rahman, Adel A. -H.
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2010, 65 (1-2): : 22 - 28
  • [50] Synthesis and evaluation of lipase inhibitory activities of substituted 1,2,4-triazole derivatives
    Ozdemir, Yusuf
    Bekircan, Olcay
    Colak, Ahmet
    Dokuzparmak, Cigdem
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2020, 59 (09): : 1409 - 1417
12345