Beyond the Linear Genome: Paired-End Sequencing as a Biophysical Tool

被引：1

作者：

Risca, Viviana I. ^{[1
]}

Greenleaf, William J. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 12期

关键词：

CHROMATIN; CONTIGUITY;

D O I：

10.1016/j.tcb.2015.08.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Paired-end sequencing has enabled a variety of new methods for high-throughput interrogation of both genome structure and chromatin architecture. Here, we discuss how the paired-end paradigm can be used to interpret sequencing data as biophysical measurements of in vivo chromatin structure that report on single molecules in single cells.

引用

页码：716 / 719

页数：4

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