Beyond the Linear Genome: Paired-End Sequencing as a Biophysical Tool

被引：1
|
作者：
Risca, Viviana I. [1 ]
Greenleaf, William J. [1 ,2 ]
机构：
[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA
来源：
TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 12期
关键词：
CHROMATIN; CONTIGUITY;
D O I：
10.1016/j.tcb.2015.08.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Paired-end sequencing has enabled a variety of new methods for high-throughput interrogation of both genome structure and chromatin architecture. Here, we discuss how the paired-end paradigm can be used to interpret sequencing data as biophysical measurements of in vivo chromatin structure that report on single molecules in single cells.
引用
收藏
页码：716 / 719
页数：4
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