Size distribution of virus laden droplets from expiratory ejecta of infected subjects

被引:93
|
作者
Anand, S. [1 ,2 ]
Mayya, Y. S. [3 ]
机构
[1] Bhabha Atom Res Ctr, Div Hlth Phys, Mumbai 400085, Maharashtra, India
[2] Bhabha Atom Res Ctr, Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, India
[3] Indian Inst Technol, Dept Chem Engn, Mumbai 400076, Maharashtra, India
关键词
AEROSOL; TRANSMISSION; SPREAD; AGENTS;
D O I
10.1038/s41598-020-78110-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
For rebooting economic activities in the ongoing COVID-19 pandemic scenario, it is important to pay detailed attention to infection transfer mechanisms during interaction of people in enclosed environments. Utmost concern is the possibility of aerosol mediated infection transfer, which is largely governed by the size distributions of virus laden droplets, termed as virusols in this work, ejected from humans. We expand on the well-known theory of Poisson fluctuations which acts as statistical barrier against formation of virusols. Analysis suggests that for viral loads < 2 x 10(5) RNA copies/mL, often corresponding to mild-to-moderate cases of COVID-19, droplets of diameter < 20 mu m at the time of emission (equivalent to similar to 10 mu m desiccated residue diameter) are unlikely to be of consequence in carrying infections. Cut-off diameters below which droplets will be practically free of contamination, are presented as a function of viral loading. The median diameters of virus laden polydisperse droplet distributions will be 1.5 to 20 times higher depending upon the geometric standard deviation. The studies have implications to risk assessment as well as residence time estimates of airborne infections in indoor environments. Additionally, it will be also helpful for performance evaluation of sanitization and control technologies to mitigate infection risks in workplaces.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil
    Giret, Maria Teresa M.
    Miraglia, Joao Luiz
    Araripe Sucupira, Maria Cecilia
    Nishiya, Anna
    Levi, Jose Eduardo
    Diaz, Ricardo S.
    Sabino, Ester C.
    Kallas, Esper G.
    PLOS ONE, 2011, 6 (04):
  • [42] Rabies virus distribution in tissues and molecular characterization of strains from naturally infected non-hematophagous bats
    Allendorf, Susan Dora
    Cortez, Adriana
    Heinemann, Marcos Bryan
    Appolinario Harary, Camila M.
    Antunes, Joao Marcelo A. P.
    Peres, Marina Gea
    Vicente, Acacia Ferreira
    Sodre, Miriam Martos
    da Rosa, Adriana Ruckert
    Megid, Jane
    VIRUS RESEARCH, 2012, 165 (02) : 119 - 125
  • [43] Species distribution & antifungal susceptibility pattern of oropharyngeal Candida isolates from human immunodeficiency virus infected individuals
    Das, Partha Pratim
    Saikia, Lahari
    Nath, Reema
    Phukan, Sanjib Kumar
    INDIAN JOURNAL OF MEDICAL RESEARCH, 2016, 143 : 495 - 501
  • [44] DROP-SIZE DISTRIBUTION OF FOG DROPLETS DETERMINED FROM TRANSMISSION MEASUREMENTS IN THE 0.53-10.1-MU-M WAVELENGTH RANGE
    LENHAM, AP
    CLAY, MR
    APPLIED OPTICS, 1982, 21 (23): : 4191 - 4193
  • [45] SIZE DISTRIBUTION AND INVITRO TRANSLATION OF RNAS ISOLATED FROM TURNIP YELLOW MOSAIC-VIRUS NUCLEOPROTEINS
    HIGGINS, TJV
    WHITFELD, PR
    MATTHEWS, REF
    VIROLOGY, 1978, 84 (01) : 153 - 161
  • [46] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND HEPATITIS-B VIRUS TRANSCRIPTION IN PERIPHERAL-BLOOD LYMPHOCYTES FROM CO-INFECTED SUBJECTS
    CLEMENTI, M
    MANZIN, A
    BAGNARELLI, P
    MENZO, S
    VARALDO, PE
    CARLONI, G
    ARCHIVES OF VIROLOGY, 1992, 126 (1-4) : 1 - 9
  • [47] Th2 Polarization in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus (HIV)-Infected Subjects, as Activated by HIV Virus-Like Particles
    Buonaguro, L.
    Tornesello, M. L.
    Gallo, R. C.
    Marincola, Franco M.
    Lewis, G. K.
    Buonaguro, F. M.
    JOURNAL OF VIROLOGY, 2009, 83 (01) : 304 - 313
  • [48] Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus
    DeBernardis, F
    Chiani, P
    Ciccozzi, M
    Pellegrini, G
    Ceddia, T
    DOffizzi, G
    Quinti, I
    Sullivan, PA
    Cassone, A
    INFECTION AND IMMUNITY, 1996, 64 (02) : 466 - 471
  • [49] A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets
    Imai, Masaki
    Watanabe, Tokiko
    Kiso, Maki
    Nakajima, Noriko
    Yamayoshi, Seiya
    Iwatsuki-Horimoto, Kiyoko
    Hatta, Masato
    Yamada, Shinya
    Ito, Mutsumi
    Sakai-Tagawa, Yuko
    Shirakura, Masayuki
    Takashita, Emi
    Fujisaki, Seiichiro
    McBride, Ryan
    Thompson, Andrew J.
    Takahashi, Kenta
    Maemura, Tadashi
    Mitake, Hiromichi
    Chiba, Shiho
    Zhong, Gongxun
    Fan, Shufang
    Oishi, Kohei
    Yasuhara, Atsuhiro
    Takada, Kosuke
    Nakao, Tomomi
    Fukuyama, Satoshi
    Yamashita, Makoto
    Lopes, Tiago J. S.
    Neumann, Gabriele
    Odagiri, Takato
    Watanabe, Shinji
    Shu, Yuelong
    Paulson, James C.
    Hasegawa, Hideki
    Kawaoka, Yoshihiro
    CELL HOST & MICROBE, 2017, 22 (05) : 615 - +
  • [50] Detection of Pneumocystis carinii and characterization of mutations associated with sulfa resistance in bronchoalveolar lavage samples from human immunodeficiency virus-infected subjects
    Zingale, A
    Carrera, P
    Lazzarin, A
    Scarpellini, P
    JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (06) : 2709 - 2712