Size distribution of virus laden droplets from expiratory ejecta of infected subjects

被引:93
|
作者
Anand, S. [1 ,2 ]
Mayya, Y. S. [3 ]
机构
[1] Bhabha Atom Res Ctr, Div Hlth Phys, Mumbai 400085, Maharashtra, India
[2] Bhabha Atom Res Ctr, Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, India
[3] Indian Inst Technol, Dept Chem Engn, Mumbai 400076, Maharashtra, India
关键词
AEROSOL; TRANSMISSION; SPREAD; AGENTS;
D O I
10.1038/s41598-020-78110-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
For rebooting economic activities in the ongoing COVID-19 pandemic scenario, it is important to pay detailed attention to infection transfer mechanisms during interaction of people in enclosed environments. Utmost concern is the possibility of aerosol mediated infection transfer, which is largely governed by the size distributions of virus laden droplets, termed as virusols in this work, ejected from humans. We expand on the well-known theory of Poisson fluctuations which acts as statistical barrier against formation of virusols. Analysis suggests that for viral loads < 2 x 10(5) RNA copies/mL, often corresponding to mild-to-moderate cases of COVID-19, droplets of diameter < 20 mu m at the time of emission (equivalent to similar to 10 mu m desiccated residue diameter) are unlikely to be of consequence in carrying infections. Cut-off diameters below which droplets will be practically free of contamination, are presented as a function of viral loading. The median diameters of virus laden polydisperse droplet distributions will be 1.5 to 20 times higher depending upon the geometric standard deviation. The studies have implications to risk assessment as well as residence time estimates of airborne infections in indoor environments. Additionally, it will be also helpful for performance evaluation of sanitization and control technologies to mitigate infection risks in workplaces.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] 5-lipoxygenase metabolism in alveolar macrophages from subjects infected with the human immunodeficiency virus
    Coffey, MJ
    Phare, SM
    Kazanjian, PH
    PetersGolden, M
    JOURNAL OF IMMUNOLOGY, 1996, 157 (01): : 393 - 399
  • [22] Size distribution of nanoparticles in the droplets ultrasonically atomized from Al2O3 suspension
    Kim, Jungsoon
    Kim, Jihyang
    Yeom, Jiyeong
    Ha, Kanglyeol
    Kim, Moojoon
    JAPANESE JOURNAL OF APPLIED PHYSICS, 2017, 56 (07)
  • [23] Assessing the size distribution of droplets in a cloud chamber from light extinction data during a transient regime
    Vajaiac, Sorin Nicolae
    Filip, Valeriu
    Stefan, Sabina
    Boscornea, Andreea
    JOURNAL OF ATMOSPHERIC AND SOLAR-TERRESTRIAL PHYSICS, 2014, 109 : 29 - 36
  • [24] Towards an accurate size distribution of emulsion droplets by merging distributions estimated from different measuring methods
    Kostoglou, Margaritis
    Karapantsios, Thodoris D.
    Chondrou, Angeliki P.
    Vlachou, Maria C.
    COLLOID AND INTERFACE SCIENCE COMMUNICATIONS, 2022, 46
  • [25] DISTRIBUTION OF VIRUS RECOVERED FROM THEUMATIC FEVER PATIENTS IN BODY OF EXPERIMENTALLY INFECTED ANIMALS
    PIROGOVA, OI
    VOPROSY VIRUSOLOGII, 1961, 6 (03): : 280 - &
  • [26] Heterogeneous distribution of TT virus of distinct genotypes in multiple tissues from infected humans
    Okamoto, H
    Nishizawa, T
    Takahashi, M
    Asabe, S
    Tsuda, F
    Yoshikawa, A
    VIROLOGY, 2001, 288 (02) : 358 - 368
  • [27] Distribution of inclusion bodies in tissues from 100 dogs infected with canine distemper virus
    Kubo, Takuya
    Kagawa, Yumiko
    Taniyama, Hiroyuki
    Hasegawa, Atsuhiko
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2007, 69 (05): : 527 - 529
  • [28] SPONTANEOUS INVITRO PRODUCTION OF VIRUS-SPECIFIC ANTIBODY BY LYMPHOCYTES FROM HIV-INFECTED SUBJECTS
    AMADORI, A
    DEROSSI, A
    FAULKNERVALLE, GP
    CHIECOBIANCHI, L
    CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1988, 46 (03): : 342 - 351
  • [29] Conical Shape Fluctuations Determine the Rate of Ion Evaporation and the Emitted Cluster Size Distribution from Multicharged Droplets
    Kwan, Victor
    Consta, Styliani
    JOURNAL OF PHYSICAL CHEMISTRY A, 2022, 126 (20): : 3229 - 3238
  • [30] Conical Shape Fluctuations Determine the Rate of Ion Evaporation and the Emitted Cluster Size Distribution from Multicharged Droplets
    Kwan, Victor
    Consta, Styliani
    Journal of Physical Chemistry A, 2022, 126 (20): : 3229 - 3238