Positively coded photoaffinity label for altering isoelectric points of proteins

被引：1
|
作者：
Hashimoto, Makoto
Hatanaka, Yasumaru
机构：
[1] Obihiro Univ Agr & Vet Med, Dept Agr & Life Sci, Obihiro, Hokkaido 0808555, Japan
[2] Toyama Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 23期
关键词：
photoaffinity labeling; diazirine; isoelectric focusing; biotin;
D O I：
10.1016/j.bmcl.2006.08.119
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel diazirinyl photoaffinity ligand, which contains (3-trifluoromethyl) phenyldiazirine and penta(epsilon-Boc-Lys) as a photoreactive code, allows the introduction of a positive cascade to alter the pI value of labeled components, facilitating the isolation of photolabeled biocomponents with isoelectric focusing techniques. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5998 / 6000
页数：3
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