The establishment and evaluation of anti-ASC amino acid transporter 2 (ASCT2) antibody as a novel therapeutic antibody for gastric cancer

被引:0
|
作者
Sasakawa, Aya [1 ]
Hosomi, Kenta [1 ]
Ishii, Toshihiko [1 ]
Ando, Hiroshi [1 ]
Suzuki, Masayo [1 ]
Imaizumi, Minami [1 ]
Zou, Jian [1 ]
Kasai, Noriyuki [2 ]
Yamano, Kazuya [1 ]
Nakamura, Kazuyasu [1 ]
Nakai, Ryuichiro [1 ]
机构
[1] Kyowa Hakko Kirin Co Ltd, Shizuoka, Japan
[2] Kyowa Kirin Pharmaceut Dev Inc, Princeton, NJ USA
关键词
D O I
10.1158/1535-7163.TARG-17-B037
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B037
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer
    Toyoda, M.
    Kaira, K.
    Ohshima, Y.
    Ishioka, N. S.
    Shino, M.
    Sakakura, K.
    Takayasu, Y.
    Takahashi, K.
    Tominaga, H.
    Oriuchi, N.
    Nagamori, S.
    Kanai, Y.
    Oyama, T.
    Chikamatsu, K.
    BRITISH JOURNAL OF CANCER, 2014, 110 (10) : 2506 - 2513
  • [42] New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak
    Grewer, C
    Grabsch, E
    JOURNAL OF PHYSIOLOGY-LONDON, 2004, 557 (03): : 747 - 759
  • [43] An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models
    Osanai-Sasakawa, Aya
    Hosomi, Kenta
    Sumitomo, Yoshiki
    Takizawa, Takuya
    Tomura-Suruki, Shiho
    Imaizumi, Minami
    Kasai, Noriyuki
    Poh, Tze Wei
    Yamano, Kazuya
    Yong, Wei Peng
    Kono, Koji
    Nakamura, Satoshi
    Ishii, Toshihiko
    Nakai, Ryuichiro
    AMERICAN JOURNAL OF CANCER RESEARCH, 2018, 8 (08): : 1499 - 1513
  • [44] Cationic amino acid transporter PQLC2 is a potential therapeutic target in gastric cancer
    Jeung, Yun-Ji
    Lee, Kyeong
    Lee, Hyo Jin
    Kim, Eunah
    Son, Myung Jin
    Ahn, Jiwon
    Kim, Han-Gyeul
    Kim, Wantae
    Lee, Ho-Joon
    Kim, Jin Man
    Chung, Kyung-Sook
    CANCER SCIENCE, 2019, 110 (04) : 1453 - 1463
  • [45] Conserved allosteric binding pocket in SLC1 glutamate transporter EAAT1 and neutral amino acid transporter ASCT2
    Dong, Yang
    Wang, Jiali
    Eisenberg, Gilad
    Yu, Xiaozhen
    Schlessinger, Avner
    Grewer, Christof T.
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 250A - 250A
  • [46] The glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Transport mechanism, regulation by ATP and characterization of the glutamine/glutamate antiport
    Oppedisano, Francesca
    Pochini, Lorena
    Galluccio, Michele
    Indiveri, Cesare
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2007, 1768 (02): : 291 - 298
  • [47] Na+-dependent neutral amino acid transporter ASCT2 is downregulated in seriously traumatized human intestinal epithelial cells
    Huang, Qian
    Li, Ning
    Zhang, Wei
    Zhu, Welming
    Li, Qiurong
    Bin Wang
    Li, Jieshou
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2008, 46 (01): : 71 - 79
  • [48] The Human SLC1A5 (ASCT2) Amino Acid Transporter: From Function to Structure and Role in Cell Biology
    Scalise, Mariafrancesca
    Pochini, Lorena
    Console, Lara
    Losso, Maria A.
    Indiveri, Cesare
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2018, 6
  • [49] System ASC activity and expression of the amino acid transporter ASCT1 in human intestinal Caco-2 cells
    Howard, A
    Gray, PA
    Ford, D
    Hirst, BH
    JOURNAL OF PHYSIOLOGY-LONDON, 2000, 527 : 21P - 22P
  • [50] Inactivation by Hg2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling
    Oppedisano, Francesca
    Galluccio, Michele
    Indiveri, Cesare
    BIOCHEMICAL PHARMACOLOGY, 2010, 80 (08) : 1266 - 1273