The establishment and evaluation of anti-ASC amino acid transporter 2 (ASCT2) antibody as a novel therapeutic antibody for gastric cancer

被引：0
|
作者：
Sasakawa, Aya [1 ]
Hosomi, Kenta [1 ]
Ishii, Toshihiko [1 ]
Ando, Hiroshi [1 ]
Suzuki, Masayo [1 ]
Imaizumi, Minami [1 ]
Zou, Jian [1 ]
Kasai, Noriyuki [2 ]
Yamano, Kazuya [1 ]
Nakamura, Kazuyasu [1 ]
Nakai, Ryuichiro [1 ]
机构：
[1] Kyowa Hakko Kirin Co Ltd, Shizuoka, Japan
[2] Kyowa Kirin Pharmaceut Dev Inc, Princeton, NJ USA
来源：
MOLECULAR CANCER THERAPEUTICS | 2018年 / 17卷 / 01期
关键词：
D O I：
10.1158/1535-7163.TARG-17-B037
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B037
引用
收藏
页数：2
相关论文
共 50 条
  • [21] The neutral amino acid transporter ASCT2 is overexpressed in human colorectal adenomas and carcinomas.
    Witte, D
    Carlson, N
    Ali, N
    Younes, M
    GASTROENTEROLOGY, 2000, 118 (04) : A286 - A286
  • [22] Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2
    Borowska, Anna M.
    Chiariello, Maria Gabriella
    Garaeva, Alisa A.
    Rheinberger, Jan
    Marrink, Siewert J.
    Paulino, Cristina
    Slotboom, Dirk J.
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [23] A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
    Alisa A. Garaeva
    Albert Guskov
    Dirk J. Slotboom
    Cristina Paulino
    Nature Communications, 10
  • [24] Na+-dependent neutral amino acid transporter ASCT2 is underexpressed in SHR kidney
    Pinho, Maria Joao Jorge
    Pinto, Vanda
    Serrao, Maria Paula
    Soares-Da-Silva, Patricio
    FASEB JOURNAL, 2007, 21 (06): : A909 - A909
  • [25] Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth
    Ye, Jianxin
    Huang, Qiang
    Xu, Jie
    Huang, Jinsheng
    Wang, Jinzhou
    Zhong, Wenjing
    Chen, Wannan
    Lin, Xinjian
    Lin, Xu
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2018, 144 (05) : 821 - 833
  • [26] Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth
    Jianxin Ye
    Qiang Huang
    Jie Xu
    Jinsheng Huang
    Jinzhou Wang
    Wenjing Zhong
    Wannan Chen
    Xinjian Lin
    Xu Lin
    Journal of Cancer Research and Clinical Oncology, 2018, 144 : 821 - 833
  • [27] Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets
    Broer, Angelika
    Fairweather, Stephen
    Broer, Stefan
    FRONTIERS IN PHARMACOLOGY, 2018, 9
  • [28] Anti-cancer effects of novel anti-ASCT2 monoclonal antibody on human colorectal cancer
    Hara, Yuta
    Masuko, Takashi
    CANCER SCIENCE, 2018, 109 : 465 - 465
  • [29] Molecular Characterization and Nutrition Regulation of the Neutral Amino Acid Transporter ASCT2 in Triploid Crucian Carp
    Mao, Zhuangwen
    Luo, Shengwei
    Zhao, Dafang
    Zhou, Xiang
    Zhang, Zilong
    Xiao, Yangbo
    Cao, Shenping
    Zhou, Yonghua
    Liu, Shaojun
    Tang, Jianzhou
    Liu, Zhen
    FISHES, 2021, 6 (04)
  • [30] Anti-tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS-mutated human colorectal cancer cells
    Hara, Yuta
    Minami, Yushi
    Yoshimoto, Soshi
    Hayashi, Natsumi
    Yamasaki, Akitaka
    Ueda, Shiho
    Masuko, Kazue
    Masuko, Takashi
    CANCER MEDICINE, 2020, 9 (01): : 302 - 312
12345