The establishment and evaluation of anti-ASC amino acid transporter 2 (ASCT2) antibody as a novel therapeutic antibody for gastric cancer

被引:0
|
作者
Sasakawa, Aya [1 ]
Hosomi, Kenta [1 ]
Ishii, Toshihiko [1 ]
Ando, Hiroshi [1 ]
Suzuki, Masayo [1 ]
Imaizumi, Minami [1 ]
Zou, Jian [1 ]
Kasai, Noriyuki [2 ]
Yamano, Kazuya [1 ]
Nakamura, Kazuyasu [1 ]
Nakai, Ryuichiro [1 ]
机构
[1] Kyowa Hakko Kirin Co Ltd, Shizuoka, Japan
[2] Kyowa Kirin Pharmaceut Dev Inc, Princeton, NJ USA
关键词
D O I
10.1158/1535-7163.TARG-17-B037
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B037
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Nγ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site
    Esslinger, CS
    Cybulski, KA
    Rhoderick, JF
    BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (04) : 1111 - 1118
  • [32] Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
    Fuchs, BC
    Bode, BP
    SEMINARS IN CANCER BIOLOGY, 2005, 15 (04) : 254 - 266
  • [33] Target the human Alanine/Serine/Cysteine Transporter 2(ASCT2): Achievement and Future for Novel Cancer Therapy
    Jiang, Hongli
    Zhang, Ning
    Tang, Tongzhong
    Feng, Feng
    Sun, Haopeng
    Qu, Wei
    PHARMACOLOGICAL RESEARCH, 2020, 158
  • [34] Transport mechanism and regulatory properties of the human amino acid transporter ASCT2 (SLC1A5)
    Scalise, Mariafrancesca
    Pochini, Lorena
    Panni, Simona
    Pingitore, Piero
    Hedfalk, Kristina
    Indiveri, Cesare
    AMINO ACIDS, 2014, 46 (11) : 2463 - 2475
  • [35] Transport mechanism and regulatory properties of the human amino acid transporter ASCT2 (SLC1A5)
    Mariafrancesca Scalise
    Lorena Pochini
    Simona Panni
    Piero Pingitore
    Kristina Hedfalk
    Cesare Indiveri
    Amino Acids, 2014, 46 : 2463 - 2475
  • [36] Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds
    Ndaru, Elias
    Garibsingh, Rachel-Ann A.
    Shi, YueYue
    Wallace, Evan
    Zakrepine, Paul
    Wang, Jiali
    Schlessinger, Avner
    Grewer, Christof
    JOURNAL OF GENERAL PHYSIOLOGY, 2019, 151 (03): : 357 - 368
  • [37] The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2
    Palmada, M
    Speil, A
    Jeyaraj, S
    Böhmer, C
    Lang, F
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 331 (01) : 272 - 277
  • [38] Underexpression of the Na+-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney
    Pinho, Maria Joao
    Pinto, Vanda
    Serrao, Maria Paula
    Jose, Pedro A.
    Soares-da-Silva, Patricio
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 293 (01) : R538 - R547
  • [39] Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells
    Broer, Angelika
    Gauthier-Coles, Gregory
    Rahimi, Farid
    van Geldermalsen, Michelle
    Dorsch, Dieter
    Wegener, Ansgar
    Holst, Jeff
    Broer, Stefan
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (11) : 4012 - 4026
  • [40] Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer
    M Toyoda
    K Kaira
    Y Ohshima
    N S Ishioka
    M Shino
    K Sakakura
    Y Takayasu
    K Takahashi
    H Tominaga
    N Oriuchi
    S Nagamori
    Y Kanai
    T Oyama
    K Chikamatsu
    British Journal of Cancer, 2014, 110 : 2506 - 2513