Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist:: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397)

被引：198

作者：

Kawamoto, H ^{[1
]}

Ozaki, S ^{[1
]}

Itoh, Y ^{[1
]}

Miyaji, M ^{[1
]}

Arai, S ^{[1
]}

Nakashima, H ^{[1
]}

Kato, T ^{[1
]}

Ohta, H ^{[1
]}

Iwasawa, Y ^{[1
]}

机构：

[1] Banyu Pharmaceut Co Ltd, Merck Res Labs, Banyu Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 42卷 / 25期

关键词：

D O I：

10.1021/jm990517p

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：5061 / 5063

页数：3

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