Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist:: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397)

被引:198
|
作者
Kawamoto, H [1 ]
Ozaki, S [1 ]
Itoh, Y [1 ]
Miyaji, M [1 ]
Arai, S [1 ]
Nakashima, H [1 ]
Kato, T [1 ]
Ohta, H [1 ]
Iwasawa, Y [1 ]
机构
[1] Banyu Pharmaceut Co Ltd, Merck Res Labs, Banyu Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan
关键词
D O I
10.1021/jm990517p
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:5061 / 5063
页数:3
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