Modified peptides from a water bloom of the cyanobacterium Nostoc sp.

被引：53
|
作者：
Ploutno, A [1 ]
Carmeli, S [1 ]
机构：
[1] Tel Aviv Univ, Sch Chem, Raymond & Beverly Sackler Fac Exact Sci, IL-69978 Tel Aviv, Israel
来源：
TETRAHEDRON | 2002年 / 58卷 / 50期
关键词：
cyanobacteria; Nostoc; protease inhibitors; cyclichexapeptides;
D O I：
10.1016/S0040-4020(02)01326-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Six new metabilites, nostopeptin BN920 (1), nostoginin BN741 (2), nostoginin BN578 (3), banyascyclamide A (4) banyascyclamide B (5) and banyascyclamide C (6), were isolated from the hydrophilic extract of a Nostoc sp. The planar structure of compounds 1-6 was determined by homonuclear and inverse-heteronuclear 2D NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centers was studied using Marfey's method for HPLC. Compound 1 inhibits the serine-protease chymotrypsin while compound 2 inhibits amino-proteases. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9949 / 9957
页数：9
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