Eight novel serine proteases inhibitors from a water bloom of the cyanobacterium Microcystis sp

被引：49
|
作者：
Zafrir-Ilan, Ella
Carmeli, Shmuel [1 ]
机构：
[1] Tel Aviv Univ, Raymond & Beverly Sackler Sch Chem, IL-69978 Tel Aviv, Israel
来源：
TETRAHEDRON | 2010年 / 66卷 / 47期
基金：
以色列科学基金会;
关键词：
Cyanobacteria; Microcystis; Micropeptins; Anabaenopeptins; Natural products; OSCILLATORIA-AGARDHII; ANABAENOPEPTINS; AERUGINOSA; PEPTIDES;
D O I：
10.1016/j.tet.2010.09.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Eight new secondary metabolites micropeptin MM836 (1) micropeptin MM850 (2) micropeptin MM916 (3) micropeptin MM932 (4) micropeptin MM978 (5) anabaenopeptin MM823 (6) anabaenopeptin MM850 (7) and anabaenopeptin MM913 (8) as well as the known anabaenopeptin B (9) were isolated from the hydrophilic extract of the cyanobacterium Microcystis sp that was collected from a fishpond in Kibbutz Ma agan Michael Israel in September 2006 The structure of the pure natural products was established by spectroscopic methods including 1D and 2D NMR, UV and MS techniques The absolute configuration of the chiral centers of the compounds was determined using Marfey s method The inhibitory activity of the compounds was determined against the serine proteases trypsin chymotrypsin thrombin and elastase (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码：9194 / 9202
页数：9
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