Modified peptides from a water bloom of the cyanobacterium Nostoc sp.

被引：53
|
作者：
Ploutno, A [1 ]
Carmeli, S [1 ]
机构：
[1] Tel Aviv Univ, Sch Chem, Raymond & Beverly Sackler Fac Exact Sci, IL-69978 Tel Aviv, Israel
来源：
TETRAHEDRON | 2002年 / 58卷 / 50期
关键词：
cyanobacteria; Nostoc; protease inhibitors; cyclichexapeptides;
D O I：
10.1016/S0040-4020(02)01326-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Six new metabilites, nostopeptin BN920 (1), nostoginin BN741 (2), nostoginin BN578 (3), banyascyclamide A (4) banyascyclamide B (5) and banyascyclamide C (6), were isolated from the hydrophilic extract of a Nostoc sp. The planar structure of compounds 1-6 was determined by homonuclear and inverse-heteronuclear 2D NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centers was studied using Marfey's method for HPLC. Compound 1 inhibits the serine-protease chymotrypsin while compound 2 inhibits amino-proteases. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9949 / 9957
页数：9
相关论文
共 50 条
  • [31] Partial Purification and Characterization of Ornithine Carbamoyl Transferase (OCT) from the Cyanobacterium Nostoc sp. Strain PCC 73102
    Eva Jansson
    Peter Lindblad
    Current Microbiology, 1998, 37 : 251 - 256
  • [32] Homology modeling and functional sites prediction of azoreductase enzyme from the cyanobacterium Nostoc sp. PCC7120
    Philem Priyadarshini Devi
    Samrat Adhikari
    Interdisciplinary Sciences: Computational Life Sciences, 2012, 4 : 310 - 318
  • [33] Partial purification and characterization of ornithine carbamoyl transferase (OCT) from the cyanobacterium Nostoc sp. strain PCC 73102
    Jansson, E
    Lindblad, P
    CURRENT MICROBIOLOGY, 1998, 37 (04) : 251 - 256
  • [34] Largamides A-H, unusual cyclic peptides from the marine cyanobacterium Oscillatoria sp.
    Plaza, Alberto
    Bewley, Carole A.
    JOURNAL OF ORGANIC CHEMISTRY, 2006, 71 (18): : 6898 - 6907
  • [35] Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin
    Schneider, Yannik K. -H.
    Liaimer, Anton
    Isaksson, Johan
    Wilhelmsen, Oda S. B.
    Andersen, Jeanette H. H.
    Hansen, Kine O.
    Hansen, Espen H. H.
    FRONTIERS IN MICROBIOLOGY, 2023, 14
  • [36] Complex arabinose-containing polysaccharides from cyanobacterium Nostoc sp.: Extraction, structural characterization and antioxidant activity
    Premarathna, Amal D.
    Rjabovs, Vitalijs
    Humayun, Sanjida
    Darko, Clarisa Naa Shormeh
    Robal, Marju
    Ahmed, Tamer A. E.
    Hincke, Maxwell T.
    Tuvikene, Rando
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 307
  • [37] The solution structure of photosystem I accessory protein E from the cyanobacterium Nostoc sp. strain PCC 8009
    Department of Chemistry, Pennsylvania State University, University Park, PA 16802, United States
    不详
    不详
    不详
    Biochem, 41 (13736-13746):
  • [38] Carbamidocyclophanes F and G with anti-Mycobacterium tuberculosis activity from the cultured freshwater cyanobacterium Nostoc sp.
    Luo, Shangwen
    Kang, Hahk-Soo
    Krunic, Aleksej
    Chlipala, George E.
    Cai, Geping
    Chen, Wei-Lun
    Franzblau, Scott G.
    Swanson, Steven M.
    Orjala, Jimmy
    TETRAHEDRON LETTERS, 2014, 55 (03) : 686 - 689
  • [39] Menominin A and B: Cytotoxic Cyclodepsipeptides from the Freshwater Sponge-Associated Cyanobacterium Nostoc sp. UIC 10607
    Davis, Lydia J.
    Krunic, Aleksej
    Alexander, Kelsey
    Khin, Manead
    Wood, Jared S.
    Earp, Cody
    Rangel-Grimaldo, Manuel
    Eustaquio, Alessandra S.
    Burdette, Joanna E.
    Williamson, R. Thomas
    Oberlies, Nicholas H.
    Orjala, Jimmy
    JOURNAL OF NATURAL PRODUCTS, 2025,
  • [40] Crystal structure of phycocyanin from heterocyst-forming filamentous cyanobacterium Nostoc sp. WR13
    Patel, Hiral M.
    Roszak, Aleksander W.
    Madamwar, Datta
    Cogdell, Richard J.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 135 : 62 - 68
12345