Structural Characteristics of the RNAse H Domain in HIV-1 Reverse Transcriptase

被引:0
|
作者
Slack, Ryan L. [1 ]
Sharaf, Naima G. [1 ]
Gronenborn, Angela M. [1 ]
Ishima, Rieko [1 ]
机构
[1] Univ Pittsburgh, Struct Biol, Pittsburgh, PA USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.bpj.2016.11.2635
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2395-Pos
引用
收藏
页码:487A / 487A
页数:1
相关论文
共 50 条
  • [21] Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site
    Himmel, Daniel M.
    Maegley, Karen A.
    Pauly, Tom A.
    Bauman, Joseph D.
    Das, Kalyan
    Dharia, Chhaya
    Clark, Arthur D., Jr.
    Ryan, Kevin
    Hickey, Michael J.
    Love, Robert A.
    Hughes, Stephen H.
    Bergqvist, Simon
    Arnold, Eddy
    STRUCTURE, 2009, 17 (12) : 1625 - 1635
  • [22] Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase
    Boyer, Paul L.
    Smith, Steven J.
    Zhao, Xue Zhi
    Das, Kalyan
    Gruber, Kevin
    Arnold, Eddy
    Burke, Terrence R., Jr.
    Hughes, Stephen H.
    JOURNAL OF VIROLOGY, 2018, 92 (13)
  • [23] X-ray Structure for an RNase H Inhibitor Bound to HIV-1 Reverse Transcriptase
    Himmel, Daniel M.
    Sarafianos, Stefan G.
    Dharmasena, Sanjeewa
    Hossain, Mofazzal
    McCoy-Simandle, Kessler
    Clark, Patrick K.
    Clark, Arthur D., Jr.
    Knight, Jennifer L.
    Levy, Ronald M.
    Hughes, Stephen H.
    Parniak, Michael A.
    Arnold, Eddy
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2005, 61 : C249 - C249
  • [24] Relationship between mutations in HIV-1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in experienced patients
    Marcelin, A
    Roquebert, B
    Malet, I
    Wirden, M
    Simon, A
    Katlama, C
    Calvez, V
    ANTIVIRAL THERAPY, 2005, 10 : S98 - S98
  • [25] Relationship between mutations in HIV-1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in experienced patients
    Marcelin, AG
    Roquebert, B
    Malet, I
    Wirden, M
    Simon, A
    Katlama, C
    Calvez, V
    ANTIVIRAL THERAPY, 2005, 10 (04) : S98 - S98
  • [26] HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently
    Li, An
    Li, Jiawen
    Johnson, Kenneth A.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (51) : 26566 - 26585
  • [27] A Structural and Dynamics Survey of HIV-1 Reverse Transcriptase
    Seckler, James M.
    Miao, Hongyu
    Grossfield, Alan M.
    BIOPHYSICAL JOURNAL, 2013, 104 (02) : 57A - 57A
  • [28] Murine leukemia virus reverse transcriptase:: Structural comparison with HIV-1 reverse transcriptase
    Cote, Marie L.
    Roth, Monica J.
    VIRUS RESEARCH, 2008, 134 (1-2) : 186 - 202
  • [29] The sequential mechanism of HIV reverse transcriptase RNase H
    Wisniewski, M
    Balakrishnan, M
    Palaniappan, C
    Fay, PJ
    Bambara, RA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) : 37664 - 37671
  • [30] Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase
    Ito, Yuma
    Lu, Huiyan
    Kitajima, Mariko
    Ishikawa, Hayato
    Nakata, Yoshihiro
    Iwatani, Yasumasa
    Hoshino, Tyuji
    JOURNAL OF NATURAL PRODUCTS, 2023, 86 (11): : 2487 - 2495