Structural Characteristics of the RNAse H Domain in HIV-1 Reverse Transcriptase

被引:0
|
作者
Slack, Ryan L. [1 ]
Sharaf, Naima G. [1 ]
Gronenborn, Angela M. [1 ]
Ishima, Rieko [1 ]
机构
[1] Univ Pittsburgh, Struct Biol, Pittsburgh, PA USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.bpj.2016.11.2635
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2395-Pos
引用
收藏
页码:487A / 487A
页数:1
相关论文
共 50 条
  • [41] Free Energy-Based Virtual Screening and Optimization of RNase H Inhibitors of HIV-1 Reverse Transcriptase
    Zhang, Baofeng
    D'Erasmo, Michael P.
    Murelli, Ryan P.
    Gallicchio, Emilio
    ACS OMEGA, 2016, 1 (03): : 435 - 447
  • [42] Data mining and molecular dynamics analysis to detect HIV-1 reverse transcriptase RNase H activity inhibitor
    Ghafoor, Naeem Abdul
    Kirboga, Kevser Kubra
    Baysal, Omur
    Suzek, Baris Ethem
    Silme, Ragip Soner
    MOLECULAR DIVERSITY, 2024, 28 (04) : 1869 - 1888
  • [43] An enzymatically active chimeric HIV-1 reverse transcriptase (RT) with the RNase-H domain of murine leukemia virus RT exists as a monomer
    Misra, HS
    Pandey, PK
    Pandey, VN
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (16) : 9785 - 9789
  • [44] A RECOMBINANT RIBONUCLEASE-H DOMAIN OF HIV-1 REVERSE-TRANSCRIPTASE THAT IS ENZYMATICALLY ACTIVE
    EVANS, DB
    BRAWN, K
    DEIBEL, MR
    TARPLEY, WG
    SHARMA, SK
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (31) : 20583 - 20585
  • [45] CRYSTAL-STRUCTURE OF THE RIBONUCLEASE-H DOMAIN OF HIV-1 REVERSE-TRANSCRIPTASE
    DAVIES, JF
    HOSTOMSKA, Z
    HOSTOMSKY, Z
    JORDAN, SR
    MATTHEWS, DA
    SCIENCE, 1991, 252 (5002) : 88 - 95
  • [46] HIV-1 reverse transcriptase inhibitors
    El Safadi, Yazan
    Vivet-Boudou, Valerie
    Marquet, Roland
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2007, 75 (04) : 723 - 737
  • [47] HIV-1 REVERSE-TRANSCRIPTASE - STRUCTURE PREDICTIONS FOR THE POLYMERASE DOMAIN
    BARBER, AM
    HIZI, A
    MAIZEL, JV
    HUGHES, SH
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (09) : 1061 - 1072
  • [48] HIV-1 reverse transcriptase inhibitors
    Lloyd, AW
    DRUG DISCOVERY TODAY, 1996, 1 (03) : 122 - 122
  • [49] HIV-1 reverse transcriptase inhibitors
    Yazan El Safadi
    Valérie Vivet-Boudou
    Roland Marquet
    Applied Microbiology and Biotechnology, 2007, 75 : 723 - 737
  • [50] The Y181C mutant of HIV-1 reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors alters the size distribution of RNase H cleavages
    Archer, RH
    Wisniewski, M
    Bambara, RA
    Demeter, LM
    BIOCHEMISTRY, 2001, 40 (13) : 4087 - 4095