X-ray Structure for an RNase H Inhibitor Bound to HIV-1 Reverse Transcriptase

被引：0
|
作者：
Himmel, Daniel M. [1 ]
Sarafianos, Stefan G. [1 ]
Dharmasena, Sanjeewa [2 ]
Hossain, Mofazzal [2 ]
McCoy-Simandle, Kessler [2 ]
Clark, Patrick K. [3 ]
Clark, Arthur D., Jr. [1 ]
Knight, Jennifer L. [4 ,5 ]
Levy, Ronald M. [4 ,5 ]
Hughes, Stephen H. [3 ]
Parniak, Michael A. [2 ]
Arnold, Eddy [1 ]
机构：
[1] Rutgers State Univ, CABM, New Brunswick, NJ USA
[2] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA
[3] NCI, Frederick Canc Res & Dev Ctr, Bethesda, MD 20892 USA
[4] Rutgers State Univ, Dept Chem & Chem Biol, New Brunswick, NJ USA
[5] Rutgers State Univ, BIOMAPS Inst Quantitat Biol, New Brunswick, NJ USA
来源：
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES | 2005年 / 61卷
关键词：
HIV-1 reverse transcriptase; RNase H inhibitor; rational inhibitor design;
D O I：
10.1107/S0108767305089397
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
P.04.15.34
引用
收藏
页码：C249 / C249
页数：1
相关论文
共 50 条
  • [1] Structure for an HIV-1 reverse transcriptase RNase H inhibitor bound at the active site
    Himmel, Daniel M.
    Pauly, Tom A.
    Bauman, Joe
    Dharia, Chhaya
    Clark, Arthur D.
    Ryan, Kevin
    Maegley, Karen A.
    Arnold, Eddy
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 : C348 - C348
  • [2] Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site
    Himmel, Daniel M.
    Maegley, Karen A.
    Pauly, Tom A.
    Bauman, Joseph D.
    Das, Kalyan
    Dharia, Chhaya
    Clark, Arthur D., Jr.
    Ryan, Kevin
    Hickey, Michael J.
    Love, Robert A.
    Hughes, Stephen H.
    Bergqvist, Simon
    Arnold, Eddy
    STRUCTURE, 2009, 17 (12) : 1625 - 1635
  • [3] HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site
    Himmel, Daniel M.
    Sarafianos, Stefan G.
    Dharmasena, Sanjeewa
    Hossain, Mohammed M.
    McCoy-Simandle, Kessler
    Ilina, Tatiana
    Clark, Arthur D., Jr.
    Knight, Jennifer L.
    Julias, John G.
    Clark, Patrick K.
    Krogh-Jespersen, Karsten
    Levy, Ronald M.
    Hughes, Stephen H.
    Parniak, Michael A.
    Arnold, Eddy
    ACS CHEMICAL BIOLOGY, 2006, 1 (11) : 702 - 712
  • [4] Solution structure of the RNase H domain of the HIV-1 reverse transcriptase in the presence of magnesium
    Pari, K
    Mueller, GA
    DeRose, EF
    Kirby, TW
    London, RE
    BIOCHEMISTRY, 2003, 42 (03) : 639 - 650
  • [5] Structural Basis of the Allosteric Inhibitor Interaction on the HIV-1 Reverse Transcriptase RNase H Domain
    Christen, Martin T.
    Menon, Lakshmi
    Myshakina, Nataliya S.
    Ahn, Jinwoo
    Parniak, Michael A.
    Ishima, Rieko
    CHEMICAL BIOLOGY & DRUG DESIGN, 2012, 80 (05) : 706 - 716
  • [6] RNASE-H DOMAIN OF HIV-1 REVERSE-TRANSCRIPTASE
    HOSTOMSKA, Z
    HOSTOMSKY, Z
    DAVIES, J
    MATTHEWS, D
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (05) : 860 - 860
  • [7] Backbone dynamics of the RNase H domain of HIV-1 reverse transcriptase
    Mueller, GA
    Pari, K
    DeRose, EF
    Kirby, TW
    London, RE
    BIOCHEMISTRY, 2004, 43 (29) : 9332 - 9342
  • [8] Structural Characteristics of the RNAse H Domain in HIV-1 Reverse Transcriptase
    Slack, Ryan L.
    Sharaf, Naima G.
    Gronenborn, Angela M.
    Ishima, Rieko
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 487A - 487A
  • [9] Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H
    Wisniewski, M
    Chen, Y
    Balakrishnan, M
    Palaniappan, C
    Roques, BP
    Fay, PJ
    Bambara, RA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (32) : 28400 - 28410
  • [10] Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase
    Figiel, Matgorzata
    Krepl, Miroslav
    Poznanski, Jaroslaw
    Gotab, Agnieszka
    Sponer, Jiri
    Nowotny, Marcin
    NUCLEIC ACIDS RESEARCH, 2017, 45 (06) : 3341 - 3352
12345