X-ray Structure for an RNase H Inhibitor Bound to HIV-1 Reverse Transcriptase

被引：0

作者：

Himmel, Daniel M. ^{[1
]}

Sarafianos, Stefan G. ^{[1
]}

Dharmasena, Sanjeewa ^{[2
]}

Hossain, Mofazzal ^{[2
]}

McCoy-Simandle, Kessler ^{[2
]}

Clark, Patrick K. ^{[3
]}

Clark, Arthur D., Jr. ^{[1
]}

Knight, Jennifer L. ^{[4
,5
]}

Levy, Ronald M. ^{[4
,5
]}

Hughes, Stephen H. ^{[3
]}

Parniak, Michael A. ^{[2
]}

Arnold, Eddy ^{[1
]}

机构：

[1] Rutgers State Univ, CABM, New Brunswick, NJ USA

[2] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA

[3] NCI, Frederick Canc Res & Dev Ctr, Bethesda, MD 20892 USA

[4] Rutgers State Univ, Dept Chem & Chem Biol, New Brunswick, NJ USA

[5] Rutgers State Univ, BIOMAPS Inst Quantitat Biol, New Brunswick, NJ USA

来源：

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES | 2005年 / 61卷

关键词：

HIV-1 reverse transcriptase; RNase H inhibitor; rational inhibitor design;

D O I：

10.1107/S0108767305089397

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

P.04.15.34

引用

页码：C249 / C249

页数：1

共 50 条

[21] Effects of Mutations in the Connection and RNase H Domains of HIV-1 Reverse Transcriptase on Drug Susceptibility
Ehteshami, Maryam
Goette, Matthias
AIDS REVIEWS, 2008, 10 (04) : 224 - 235
[22] Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
Pata, JD
Stirtan, WG
Goldstein, SW
Steitz, TA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) : 10548 - 10553
[23] Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action
Freisz, Severine
Bec, Guillaume
Radi, Marco
Wolff, Philippe
Crespan, Emmanuele
Angeli, Lucilla
Dumas, Philippe
Maga, Giovanni
Botta, Maurizio
Ennifar, Eric
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (10) : 1805 - 1808
[24] Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase
Boyer, Paul L.
Smith, Steven J.
Zhao, Xue Zhi
Das, Kalyan
Gruber, Kevin
Arnold, Eddy
Burke, Terrence R., Jr.
Hughes, Stephen H.
JOURNAL OF VIROLOGY, 2018, 92 (13)
[25] STRUCTURE OF THE RIBONUCLEASE H DOMAIN OF HIV-1 REVERSE-TRANSCRIPTASE
MATTHEWS, DA
HOSTOMSKA, Z
HOSTOMSKY, Z
DAVIES, J
JORDAN, S
FASEB JOURNAL, 1992, 6 (01): : A266 - A266
[26] Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H
Palaniappan, C
Fuentes, GM
RodriguezRodriguez, L
Fay, PJ
Bambara, RA
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (04) : 2063 - 2070
[27] HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently
Li, An
Li, Jiawen
Johnson, Kenneth A.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (51) : 26566 - 26585
[28] Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo
Julias, JG
McWilliams, MJ
Sarafianos, SG
Arnold, E
Hughes, SH
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (14) : 9515 - 9520
[29] Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors
Su, Hua-Poo
Yan, Youwei
Prasad, G. Sridhar
Smith, Robert F.
Daniels, Christopher L.
Abeywickrema, Pravien D.
Reid, John C.
Loughran, H. Marie
Kornienko, Maria
Sharma, Sujata
Grobler, Jay A.
Xu, Bei
Sardana, Vinod
Allison, Timothy J.
Williams, Peter D.
Darke, Paul L.
Hazuda, Daria J.
Munshi, Sanjeev
JOURNAL OF VIROLOGY, 2010, 84 (15) : 7625 - 7633
[30] The sequential mechanism of HIV reverse transcriptase RNase H
Wisniewski, M
Balakrishnan, M
Palaniappan, C
Fay, PJ
Bambara, RA
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) : 37664 - 37671

← 1 2 3 4 5 →