Cisplatin binding to human serum albumin: a structural study

被引：109

作者：

Ferraro, Giarita ^{[1
]}

Massai, Lara ^{[2
]}

Messori, Luigi ^{[2
]}

Merlino, Antonello ^{[1
,3
]}

机构：

[1] Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy

[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, FI, Italy

[3] CNR Inst Biostruct & Bioimages, I-80126 Naples, Italy

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 46期

关键词：

X-RAY-STRUCTURE; SECONDARY STRUCTURE; MASS-SPECTROMETRY; CRYSTAL-STRUCTURE; IN-VITRO; PLATINUM; ANTICANCER; PROTEINS; ADDUCTS; CARBOPLATIN;

D O I：

10.1039/c5cc01751c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.

引用

页码：9436 / 9439

页数：4

共 50 条

[41] Structural and electronic determinants of flavonoid binding to human serum albumin: an extensive ligand-based study
Rimac, Hrvoje
Debeljak, Zeljko
Sakic, Davor
Weitner, Tin
Gabricevic, Mario
Vrcek, Valerije
Zorc, Branka
Bojic, Mirza
RSC ADVANCES, 2016, 6 (79) : 75014 - 75022
[42] Interaction of cisplatin with human serum albumin. Drug binding mode and protein secondary structure
Neault, JF
Tajmir-Riahi, HA
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1998, 1384 (01): : 153 - 159
[43] Co-amoxiclav Effects on the Structural and Binding Properties of Human Serum Albumin
Takallu, Saeed Hesami
Tavirani, Mostafa Rezaei
Kalantari, Shiva
Bakhtiarvand, Mahrooz Amir
Mahdavi, Sayed Mohammad
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2010, 9 (03): : 251 - 257
[44] STRUCTURAL REQUIREMENTS FOR BINDING OF AROMATIC COMPOUNDS TO THYROXINE-BINDING SITE ON HUMAN SERUM ALBUMIN
TABACHNI.M
GIORGIOJ.NA
FEDERATION PROCEEDINGS, 1969, 28 (02) : 260 - &
[45] Structural specificity requirements in the binding of beta lactam antibiotics to human serum albumin
Nerli, B
Romanini, D
Pico, G
CHEMICO-BIOLOGICAL INTERACTIONS, 1997, 104 (2-3) : 179 - 202
[46] Investigation of structural changes in human serum albumin after binding with elaidic acid
Shafaei, Peymaneh
Rastegari, Ali Asghar
Fouladgar, Masoud
Taheri-Kafrani, Asghar
Moshtaghie, Seyed Ali Asghar
JOURNAL OF MOLECULAR STRUCTURE, 2023, 1272
[47] Biophysical Insight into Furosemide Binding to Human Serum Albumin: A Study To Unveil Its Impaired Albumin Binding in Uremia
Zaidi, Nida
Ahmad, Ejaz
Rehan, Mohd
Rabbani, Gulam
Ajmal, Mohammad R.
Zaidi, Yusra
Subbarao, Naidu
Khan, Rizwan H.
JOURNAL OF PHYSICAL CHEMISTRY B, 2013, 117 (09): : 2595 - 2604
[48] A comprehensive biophysical and theoretical study on the binding of dexlansoprazole with human serum albumin
Bodapati, Anna Tanuja Safala
Reddy, Ragaiahgari Srinivas
Lavanya, Kandikonda
Madku, Shravya Rao
Sahoo, Bijaya Ketan
JOURNAL OF MOLECULAR LIQUIDS, 2023, 380
[49] A fluorescence study of human serum albumin binding sites modification by hypochlorite
Lissi, Eduardo
Alicia Biasutti, M.
Abuin, Elsa
Leon, Luis
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2009, 94 (02) : 77 - 81
[50] The Binding of Benzopyranes to Human Serum Albumin. A Structure–Affinity Study
Juan Manuel Ferrer
María Jesús Leiton
Ana María Lourdes Zatón
Journal of Protein Chemistry, 1998, 17 : 115 - 119

← 1 2 3 4 5 →